{{Rsnum
|rsid=324420
|Gene=FAAH
|Chromosome=1
|position=46405089
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=A
|GMAF=0.2484
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=FAAH
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 4.4 | 32.7 | 62.8
| HCB | 3.6 | 19.7 | 76.6
| JPT | 1.8 | 31.2 | 67.0
| YRI | 15.8 | 58.2 | 26.0
| ASW | 5.3 | 49.1 | 45.6
| CHB | 3.6 | 19.7 | 76.6
| CHD | 1.8 | 26.6 | 71.6
| GIH | 5.9 | 26.7 | 67.3
| LWK | 11.8 | 40.9 | 47.3
| MEX | 3.4 | 39.7 | 56.9
| MKK | 7.1 | 38.5 | 54.5
| TSI | 2.9 | 24.5 | 72.5
| HapMapRevision=28
}}[[rs324420]] is a SNP, also known as Pro129Thr, in the fatty acid amide hydrolase [[FAAH]] gene, which has shown associations with some substance use disorders. [[rs324420]](C) encodes the more common Pro, while the (A) allele encodes the Thr.

Among 80 individuals with [[drug abuse]] or [[alcoholism]] and over 1,000 controls, the odds ratio for risk of problem drug or alcohol use among [[rs32440]](A;A) individuals was 4.5 (CI: 2.2 - 8.4); the odds ratio for risk of street drug use was 2.2 (CI: 1.3–3.7); and the odds ratio for risk of combined street drug use and problem drug/alcohol use was 4.9 (CI: 2.5–9.7){{PMID|12060782|OA=1
}}

When this study was pooled with the results of another study of 249 subjects with documented multiple different drug addictions compared to drug free individuals of the same ethnic backgrounds, the results were consistent and even more significant (p = 0.00003). Risk for drug dependence (and [[drug abuse]] was associated with [[rs324420]](A;A) homozygotes. {{PMID|16972078}}

In a study of 40 daily marijuana users who abstained for 24 h and were then presented with a cue-elicited craving paradigm, followed by smoking a marijuana cigarette, [[rs324420]](A) was significantly associated with changes in withdrawal after abstinence and with happiness after smoking marijuana, but was not associated with changes in heart rate after smoking or with changes in craving or other acute effects.{{PMID|19002671|OA=1
}}

* See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602935 OMIM]

{{PMID Auto
|PMID=19958092
|Title=Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent
|OA=1
}}
{{PMID Auto
|PMID=20044928
|Title=Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
|OA=1
}}

{{PMID Auto
|PMID=20010552
|Title=Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues
|OA=1
}}

{{PharmGKB
|RSID=rs324420
|Name_s=FAAH:385C>A; FAAH:Pro129Thr
|Gene_s=FAAH
|Feature=
|Evidence=PubMed ID:17290447
|Annotation=Risk or phenotype-associated allele: A Phenotype: Homozygous AA individuals were less likely to be cannabinoid dependent. Study size: 749 Study population/ethnicity: Healthy Caucasian Volunteers; Toronto, Canada Significance metric(s): p < 0.05 Type of association: CO
|Drugs=
|Drug Classes=CANNABINOIDS
|Diseases=Substance-Related Disorders
|Curation Level=Curated
|PharmGKB Accession ID=PA165111693
}}

{{PharmGKB
|RSID=rs324420
|Name_s=C385A; Pro129Thr
|Gene_s=FAAH
|Feature=
|Evidence=PubMed ID:19958092
|Annotation=Risk or phenotype-associated allele: A. Phenotype: This nonsynonymous coding variant is associated with increased BMI, increased triglycerides, and reduced levels of high-density lipoprotein cholesterol. This is independent of insulin response. Study size: 1644 individuals from 261 families of northern european ancestry. Study population/ethnicity: northern european. Significance metric(s): BMI (P=0.042); fasting TG (p=0.022); HDL (p = 0.007). Type of association: GN; CO
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Curated
|PharmGKB Accession ID=PA165111626
}}

{{omim
|id=602935
|rsnum=324420
|variant=0001
}}

{{PMID Auto
|PMID=22068813
|Title=The Fatty Acid Amide Hydrolase (FAAH) Gene Variant rs324420 AA/AC is not Associated with Weight Loss in a 1-Year Lifestyle Intervention for Obese Children and Adolescents
}}

{{ClinVar
|rsid=324420
|Reversed=0
|FwdREF=C
|FwdALT=A
|REF=C
|ALT=A
|RSPOS=46405089
|CHROM=1
|GMAF=0.2482
|dbSNPBuildID=79
|SSR=0
|SAO=1
|VP=0x050368000a0517051f110101
|GENEINFO=FAAH:2166
|GENE_NAME=FAAH
|GENE_ID=2166
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.46405089C>A
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;S3D;SLO;NSM;REF;ASP;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.7516; 0.2484
|CLNACC=RCV000007116.2
|CLNDBN=Drug addiction, susceptibility to
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNSRCID=NM_001441.2:c.385C>A; 602935.0001
|COMMON=1
|Disease=Drug addiction
}}

{{PMID Auto
|PMID=15986317
|Title=Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.
|OA=1
}}

{{PMID Auto
|PMID=17216208
|Title=The functional Pro129Thr variant of the FAAH gene is not associated with various fat accumulation phenotypes in a population-based cohort of 5,801 whites.
}}

{{PMID Auto
|PMID=17847002
|Title=An LRP8 variant is associated with familial and premature coronary artery disease and myocardial infarction.
|OA=1
}}

{{PMID Auto
|PMID=17991615
|Title=Rapid screening for potentially relevant polymorphisms in the human fatty acid amide hydrolase gene using Pyrosequencing.
}}

{{PMID Auto
|PMID=18705688
|Title=Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes.
|OA=1
}}

{{PMID Auto
|PMID=19014633
|Title=Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa.
|OA=1
}}

{{PMID Auto
|PMID=19053981
|Title=The role of fatty acid hydrolase gene variants in inflammatory bowel disease.
}}

{{PMID Auto
|PMID=19335651
|Title=Candidate genes for cannabis use disorders: findings, challenges and directions.
|OA=1
}}

{{PMID Auto
|PMID=19659925
|Title=Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.
}}

{{PMID Auto
|PMID=19890266
|Title=More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine.
|OA=1
}}

{{PMID Auto
|PMID=20033240
|Title=Eating disorders: the current status of molecular genetic research.
|OA=1
}}

{{PMID Auto
|PMID=20054193
|Title=Evaluating the association of FAAH common gene variation with childhood, adult severe obesity and type 2 diabetes in the French population.
}}

{{PMID Auto
|PMID=20080186
|Title=Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression.
}}

{{PMID Auto
|PMID=20631561
|Title=Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain.
}}

{{PMID Auto
|PMID=21477106
|Title=Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity.
|OA=1
}}

{{PMID Auto
|PMID=21803011
|Title=Pharmacogenetic trial of a cannabinoid agonist shows reduced fasting colonic motility in patients with nonconstipated irritable bowel syndrome.
|OA=1
}}

{{PMID Auto
|PMID=22288893
|Title=Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea.
|OA=1
}}

{{PMID Auto
|PMID=22688188
|Title=Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
}}

{{PMID Auto
|PMID=23048207
|Title=Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
|OA=1
}}

{{GET Evidence
|gene=FAAH
|aa_change=Pro129Thr
|aa_change_short=P129T
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs324420
|overall_frequency_n=2753
|overall_frequency_d=10758
|overall_frequency=0.255903
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=41
|n_articles=2
|n_articles_annotated=2
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|in_omim=Y
|in_pharmgkb=Y
|pph2_score=0.001
|nblosum100=4
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24407958
|Title=Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures
}}

{{PMID Auto
|PMID=23333123
|Title=Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}