{{Rsnum
|rsid=324640
|Gene=CHRM2
|Chromosome=7
|position=137004249
|Orientation=plus
|GMAF=0.4325
|Gene_s=CHRM2,LOC349160
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 19.6 | 51.8 | 28.6
| HCB | 0.0 | 10.8 | 89.2
| JPT | 0.0 | 10.5 | 89.5
| YRI | 48.3 | 33.3 | 18.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 10.8 | 89.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}SNPs in the [[SNAP25]] gene were initially {{PMID|17160701}} linked to [[intelligence]] but have failed to replicate {{PMID|19418213}}.

While now suspect, the original work can be found in {{PMID|17160701}} and {{PMID|17081262}} or this [http://www.tweelingenregister.org/nederlands/verslaggeving/congresbezoek/Gosso_ESHG_2006.pdf pdf poster] show association between the [[CHRM2]] gene and [[intelligence]] . In this study of ~300 Caucasians, the (G;G) genotype appeared to typically have a 4 point higher IQ than the (A;G) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, [[rs324650]], showed similar results to [[rs324640]], and was in linkage disequilibrium (r2 = 0.90) with it. {{PMID|17081262}}

{{PMID Auto
|PMID=18979273
|Title=Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction
}}

{{PMID Auto
|PMID=16501017
|Title=Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism.
}}

{{PMID Auto
|PMID=17996044
|Title=Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.
|OA=1
}}

{{PMID Auto
|PMID=18634760
|Title=Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}