{{Rsnum
|rsid=324650
|Gene=CHRM2
|Chromosome=7
|position=137008914
|Orientation=plus
|GMAF=0.4421
|Gene_s=CHRM2,LOC349160
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 28.3 | 47.8 | 23.9
| HCB | 0.0 | 14.6 | 85.4
| JPT | 1.8 | 21.2 | 77.0
| YRI | 55.8 | 38.1 | 6.1
| ASW | 47.4 | 45.6 | 7.0
| CHB | 0.0 | 14.6 | 85.4
| CHD | 0.0 | 11.0 | 89.0
| GIH | 5.0 | 36.6 | 58.4
| LWK | 56.4 | 38.2 | 5.5
| MEX | 15.5 | 44.8 | 39.7
| MKK | 51.9 | 41.0 | 7.1
| TSI | 25.5 | 53.9 | 20.6
| HapMapRevision=28
}}
In 2009, a  large, multi-sample replication study failed to find any significant association with Intelligence for this or other SNPs in CHRM2 {{PMID|19418213}}.

Earlier work had observed that this [[snp]] (and perhaps its neighbors) influenced intelligence and [[alcohol dependence]]

{{PMID|16000316}} [[CHRM2]] gene predisposes to [[alcohol dependence]], [[drug dependence]] and affective disorders: results from an extended case-control structured association study. And the earlier {{PMID|15229186}}

{{PMID|17160701}} and {{PMID|17081262}} or this [http://www.tweelingenregister.org/nederlands/verslaggeving/congresbezoek/Gosso_ESHG_2006.pdf pdf poster] show association between the [[CHRM2]] gene and [[intelligence]] . In this study of ~300 Caucasians, the (T;T) genotype appeared to typically have a 4 point higher IQ than the (A;T) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, [[rs324640]], showed similar results to [[rs324650]], and was in linkage disequilibrium (r2 = 0.90) with it. {{PMID|17081262}}.  

{{omim
|desc=ALCOHOL DEPENDENCE
|id=103780
|rsnum=324650
}}

{{omim
|desc=MAJOR DEPRESSIVE DISORDER; MDD
|id=608516
|rsnum=324650
}}

{{omim
|desc=CHOLINERGIC RECEPTOR, MUSCARINIC, 2; CHRM2
|id=118493
|rsnum=324650
}}
{{PMID Auto
|PMID=19644963
|Title=Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction
}}

{{PMID Auto
|PMID=20351719
|Title=Genetic variation in cholinergic muscarinic-2 receptor gene modulates M(2) receptor binding in vivo and accounts for reduced binding in bipolar disorder
|OA=1
}}
{{PMID Auto
|PMID=21176104
|Title=Association of CHRM2 polymorphisms with severity of alcohol dependence
}}

{{PMID|17373692|OA=1
}} No evidence for association between 19 cholinergic genes and bipolar disorder.

{{PMID|17996044|OA=1
}} Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study.

{{PMID|18634760|OA=1
}} Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes.

{{PMID|19181679}} Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}