{{Rsnum
|rsid=324981
|Gene=NPSR1
|Chromosome=7
|position=34778501
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=T
|GMAF=0.4826
|Gene_s=NPSR1,NPSR1-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 29.2 | 39.8 | 31.0
| HCB | 25.5 | 46.0 | 28.5
| JPT | 19.5 | 55.8 | 24.8
| YRI | 15.0 | 46.3 | 38.8
| ASW | 33.3 | 52.6 | 14.0
| CHB | 25.5 | 46.0 | 28.5
| CHD | 18.3 | 50.5 | 31.2
| GIH | 45.5 | 40.6 | 13.9
| LWK | 32.7 | 56.4 | 10.9
| MEX | 32.8 | 51.7 | 15.5
| MKK | 43.6 | 42.3 | 14.1
| TSI | 30.4 | 51.0 | 18.6
| HapMapRevision=28
}}{{omim
|desc=ASTHMA SUSCEPTIBILITY 2
|id=608595
|rsnum=324981
|variant=0001
}}

[[asthma]] related

influences [[sleep]] patterns [http://originsgenomeresources.net/musings/?p=62]

{{PMID Auto
|PMID=20603625
|Title=Neuropeptide S receptor gene - converging evidence for a role in panic disorder
}}

{{PMID Auto
|PMID=21525857
|Title=Neuropeptide-S (NPS) Receptor Genotype Modulates Basolateral Amygdala Responsiveness to Aversive Stimuli
|OA=1
}}

{{PMID Auto
|PMID=22216302
|Title=Multiple Polymorphisms Affect Expression and Function of the Neuropeptide S Receptor (NPSR1)
|OA=1
}}

{{ClinVar
|rsid=324981
|Reversed=0
|FwdREF=A
|FwdALT=T
|REF=A
|ALT=T
|RSPOS=34818113
|CHROM=7
|GMAF=0.4817
|dbSNPBuildID=79
|SSR=0
|SAO=1
|VP=0x05036800000017051f110101
|GENEINFO=NPSR1-AS1:404744; NPSR1:387129
|GENE_NAME=NPSR1-AS1; NPSR1
|GENE_ID=404744; 387129
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.34818113A>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=608595.0001
|CLNSIG=255
|CLNCUI=C1837811
|CLNDBN=ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 2
|Disease=ASTHMA-RELATED TRAITS
|CLNACC=RCV000002276.1
|Tags=PM;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.5174; 0.4826
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1837811:608584
|COMMON=1
}}

{{PMID Auto
|PMID=16522461
|Title=G protein-coupled receptor 154 gene polymorphism is associated with airway hyperresponsiveness to methacholine in a Chinese population.
}}

{{PMID Auto
|PMID=17702965
|Title=Comprehensive testing of positionally cloned asthma genes in two populations.
|OA=1
}}

{{PMID Auto
|PMID=17903308
|Title=Genome-wide association of sleep and circadian phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18340359
|Title=Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy.
|OA=1
}}

{{PMID Auto
|PMID=20179762
|Title=Analysis of neuropeptide S receptor gene (NPSR1) polymorphism in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=22078257
|Title=The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response.
}}

{{PMID Auto
|PMID=22399050
|Title=Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation.
}}

{{GET Evidence
|gene=NPSR1
|aa_change=Asn107Ile
|aa_change_short=N107I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs324981
|overall_frequency_n=5265
|overall_frequency_d=10758
|overall_frequency=0.489403
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=53
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|in_omim=Y
|nblosum100=7
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23680103
|Title=The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder
}}

{{PMID Auto
|PMID=23319044
|Title=Neuropeptide S receptor (NPSR1) gene variation modulates response inhibition and error monitoring.
}}

{{PMID Auto
|PMID=23663310
|Title=Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.
|OA=1
}}

{{PMID Auto
|PMID=24754478
|Title=Neuropeptide S receptor gene variant and environment: contribution to alcohol use disorders and alcohol consumption
}}

{{PMID Auto
|PMID=24800784
|Title=A functional variant in the neuropeptide S receptor 1 gene moderates the influence of urban upbringing on stress processing in the amygdala
}}

{{PMID Auto
|PMID=24896296
|Title=Genetic Association of Objective Sleep Phenotypes with a Functional Polymorphism in the Neuropeptide S Receptor Gene
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}