{{Rsnum
|rsid=326
|Gene=LPL
|Chromosome=8
|position=19961928
|Orientation=plus
|GMAF=0.3457
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LPL
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 53.1 | 35.4 | 11.5
| HCB | 65.7 | 31.4 | 2.9
| JPT | 65.5 | 27.4 | 7.1
| YRI | 15.6 | 42.2 | 42.2
| ASW | 28.1 | 54.4 | 17.5
| CHB | 65.7 | 31.4 | 2.9
| CHD | 61.5 | 33.0 | 5.5
| GIH | 66.3 | 31.7 | 2.0
| LWK | 16.4 | 40.0 | 43.6
| MEX | 51.7 | 36.2 | 12.1
| MKK | 16.0 | 51.9 | 32.1
| TSI | 44.1 | 41.2 | 14.7
| HapMapRevision=28
}}
The (A) allele of [[rs326]] was associated with risk for lower high-density lipoprotein (HDL) cholesterol plasma levels in 3 independent population samples, including both Caucasians and African-Americans.{{PMID|17952847|OA=1
}}

{{PMID Auto GWAS
|PMID=18193046
|Trait=Triglycerides
|Title=Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
|RiskAllele=A
|Pval=4.9999999999999997E-12
|OR=6.60
|ORtxt=[3.66-9.54] % higher
}}

{{omim
|id=609708
|desc=LIPOPROTEIN LIPASE; LPL
|rsnum=326
}}

{{PharmGKB
|RSID=rs326
|Name_s=
|Gene_s=LPL
|Feature=
|Evidence=PubMed ID:17952847
|Annotation=This SNP has been associated with small changes in HDL cholesterol levels. The A allele has been correlated with lower HDL.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161613798
}}

{{omim
|id=609708
|rsnum=326
|variant=0042
}}

{{PMID Auto
|PMID=21149302
|Title=Effects of genetic variants on lipid parameters and dyslipidemia in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=15980532
|Title=SOP3v2: web-based selection of oligonucleotide primer trios for genotyping of human and mouse polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=20150529
|Title=Associations of lipoprotein lipase gene polymorphisms with longitudinal plasma lipid trends in young adults: The Coronary Artery Risk Development in Young Adults (CARDIA) study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs326
|overall_frequency_n=50
|overall_frequency_d=128
|overall_frequency=0.390625
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=43
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23726366
  |Trait=Triglycerides
  |Title=Genome-wide Characterization of Shared and Distinct Genetic Components that Influence Blood Lipid Levels in Ethnically Diverse Human Populations.
  |RiskAllele=T
  |Pval=1E-8
  |OR=.04
  |ORtxt=[NR] unit decrease
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}