{{Rsnum
|rsid=33917740
|Gene=SERPINI1
|Chromosome=3
|position=167789149
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.1134
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=SERPINI1
}}{{Venter SNP
|rsid=33917740
|allele=G
|frequency=
|uid=1103656290410
|type=heterozygous_SNP
|hugo=SERPINI1
|ensembl gene=ENSG00000163536
|ensembl transcript=ENST00000295777
|sift=AFFECT FUNCTION
|disease=Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) (MIM:604218). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
}}

{{GET Evidence
|gene=SERPINI1
|aa_change=Phe7Leu
|aa_change_short=F7L
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs33917740
|overall_frequency_n=1359
|overall_frequency_d=10758
|overall_frequency=0.126325
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=14
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.001
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}