{{Rsnum
|rsid=33927012
|Gene=SDHB
|Chromosome=1
|position=17027802
|Orientation=plus
|GMAF=0.007805
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SDHB
}}{{omim
|id=185470
|rsnum=33927012
|variant=0015
}}

{{ClinVar
|rsid=33927012
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=17027802
|CHROM=1
|GMAF=0.0078
|dbSNPBuildID=126
|SSR=0
|SAO=1
|VP=0x050368000a05040516110110
|GENEINFO=SDHB:6390
|GENE_NAME=SDHB
|GENE_ID=6390
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.17027802A>G
|CLNSRC=Ambry Genetics; ClinVar; LabCorp; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=a9383; NM_003000.2:c.487T>C; 185470.0015
|CLNSIG=5
|CLNCUI=C2676500
|CLNDBN=Cowden-like syndrome; Hereditary Paraganglioma-Pheochromocytoma Syndromes; Pheochromocytoma; not provided; AllHighlyPenetrant; Neoplastic Syndromes, Hereditary
|Disease=Cowden-like syndrome; Hereditary Paraganglioma-Pheochromocytoma Syndromes; Pheochromocytoma; not provided; AllHighlyPenetrant; Neoplastic Syndromes
|CLNACC=RCV000013633.16; RCV000030622.1; RCV000034688.1; RCV000122002.1; RCV000132153.1
|Tags=RV;PM;PMC;S3D;SLO;NSM;REF;ASP;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM;NOC
|CAF=0.9922; 0.007805
|CLNDSDB=MedGen:OMIM:Orphanet; GeneReviews:MedGen; GeneReviews:MedGen:OMIM:Orphanet; MedGen
|CLNDSDBID=C2676500:612359:ORPHA201; NBK1548:C1708353; NBK1548:C0031511:171300:ORPHA29072; C0027672
|COMMON=1
}}

{{PMID Auto
|PMID=17298
|Title=Immunologic studies and clinical follow-up HBsAg-positive polyarteritis nodosa.
}}

{{PMID Auto
|PMID=16912137
|Title=High frequency of SDHB germline mutations in patients with malignant catecholamine-producing paragangliomas: implications for genetic testing.
}}

{{PMID Auto
|PMID=17639058
|Title=Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.
}}

{{PMID Auto
|PMID=18551016
|Title=High prevalence of SDHB mutations in head and neck paraganglioma in Belgium.
}}

{{PMID Auto
|PMID=18678321
|Title=Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes.
|OA=1
}}

{{PMID Auto
|PMID=19802898
|Title=Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD.
}}

{{GET Evidence
|gene=SDHB
|aa_change=Ser163Pro
|aa_change_short=S163P
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs33927012
|overall_frequency_n=112
|overall_frequency_d=10758
|overall_frequency=0.0104109
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=2
|n_articles_annotated=2
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|qualityscore_case_control=2
|qualitycomment_case_control=Y
|gene_in_genetests=Y
|in_omim=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=3
|autoscore=5
|webscore=N
|n_web_uneval=10
|variant_evidence=0
|clinical_importance=0
|summary_short=We evaluate as uncertain but presumed benign. One report linked this variant to Cowden-like syndromes, but the significance of their findings is unclear and other reports treat this as a non-pathological variation.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}