{{Rsnum
|rsid=33930165
|Gene=HBB
|Chromosome=11
|position=5227003
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.002296
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HBB
}}[[rs33930165]] is a relatively rare SNP found in the beta hemoglobin [[HBB]] gene, adjacent to the well-known SNP associated with malarial resistance ([[rs334]]). This SNP gives rise to the "Hb C", or hemoglobin C, form of hemoglobin as the HBB forms are commonly named. It is found primarily in a subset of West Africa.

[[rs33930165]] is associated with increased malarial resistance, yet without giving rise to sickle cell anemia. A study of 4,000+ individuals in Burkina Faso found that [[rs33930165]](A;G) heterozygotes had a 29% reduction in risk of clinical malaria (p = 0.0008), and [[rs33930165]](C;C) homozygotes had a 93% reduction (p = 0.0011).{{PMID|11713529}}

{{omim
|id=141900
|rsnum=33930165
|variant=0010
}}

{{omim
|id=141900
|rsnum=33930165
|variant=0038
}}

{{omim
|id=141900
|rsnum=33930165
|variant=0166
}}

{{PMID Auto
|PMID=21451558
|Title=Evidence for epistasis between hemoglobin C and immune genes in human P. falciparum malaria: a family study in Burkina Faso
}}

{{ClinVar
|rsid=33930165
|Reversed=1
|FwdREF=G
|FwdALT=A,C
|REF=C
|ALT=G,T
|RSPOS=5248233
|CHROM=11
|GMAF=0.0023
|dbSNPBuildID=126
|SSR=0
|SAO=1
|VP=0x050368000000040516110100
|GENEINFO=HBB:3043
|GENE_NAME=HBB
|GENE_ID=3043
|WGT=0
|VC=SNV
|CLNALLE=1; 2
|CLNHGVS=NC_000011.9:g.5248233C>G; NC_000011.9:g.5248233C>T
|CLNORIGIN=1
|CLNSRCID=
229; 141900.0166; GTR000500319; 227; 141900.0010; 141900.0038
|CLNSIG=255
|CLNCUI=
|CLNACC=
RCV000016448.1; RCV000016251.1; RCV000016284.1; RCV000016285.24
|Tags=RV;PM;PMC;S3D;SLO;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9977; 0.002296
|CLNDBN=HEMOGLOBIN MACHIDA; HEMOGLOBIN ARLINGTON PARK; HEMOGLOBIN C; Malaria, resistance to
|CLNDSDB=MedGen
|CLNDSDBID=C2720293
|CLNSRC=HBVAR; OMIM Allelic Variant; GTR
|COMMON=1
|Disease=HEMOGLOBIN MACHIDA; HEMOGLOBIN ARLINGTON PARK; HEMOGLOBIN C; Malaria
}}

{{PMID Auto
|PMID=6129204
|Title=Hemoglobin Machida [beta 6 (A3) Glu replaced by Gln], a new abnormal hemoglobin discovered in a Japanese family: structure, function and biosynthesis.
}}

{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}