{{Rsnum
|rsid=33949390
|Gene=LRRK2
|Chromosome=12
|position=40320043
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.005051
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=LRRK2
}}Also known as R1628P, [[rs33949390]] is a SNP in the [[LRRK2]] gene.

A study of Chinese patients with [[Parkinson's disease]] concluded that in this population, after adjustments were made for age, age of onset, and gender, [[rs33949390]](C) carriers were 3.3x more likely to develop the disease than noncarriers (CI: 1.4- 7.9, p = 0.007).{{PMID|18781329}}

{{omim
|desc=LEUCINE-RICH REPEAT KINASE 2; LRRK2
|id=609007
|rsnum=33949390
}}
{{PMID Auto
|PMID=19854095
|Title=The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population
}}

{{PMID Auto
|PMID=20186690
|Title=Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.
}}

{{ClinVar
|ALT=A,C
|CAF=0.9949; 0.005051
|CHROM=12
|CLNACC=RCV000032472.1
|CLNALLE=2
|CLNDBN=Parkinson disease 8, autosomal dominant
|CLNDSDB=GeneReviews:GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1208:NBK1223:C1846862:607060:2828
|CLNHGVS=NC_000012.11:g.40713845G>C
|CLNSIG=5
|CLNSRC=GeneReviews
|CLNSRCID=NBK1208
|COMMON=1
|Disease=Parkinson disease 8
|FwdALT=A,C
|FwdREF=G
|GENEINFO=LRRK2:120892
|GENE_ID=120892
|GENE_NAME=LRRK2
|REF=G
|RSPOS=40713845
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|VC=SNV
|VP=0x050168000000040516110100
|WGT=0
|dbSNPBuildID=126
|rsid=33949390
}}

{{PMID Auto
|PMID=18412265
|Title=Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}