{{Rsnum
|rsid=33950507
|Gene=HBB
|Chromosome=11
|position=5226943
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.0004591
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=HBB
}}[[rs33950507]] is a SNP found in the beta hemoglobin [[HBB]] gene, not far from the well-known SNP associated with malarial resistance ([[rs334]], Hb S). This SNP gives rise to the "Hb E", or hemoglobin E, form of hemoglobin as the HBB forms are commonly named. It is found primarily in Southeast Asia.

[[rs33950507]](A) is associated with somewhat increased malarial resistance, and in homozygous (A;A) state, with mild hypochromic microcytic anemia.{{PMID|16114182}}
{{omim
|id=141900
|rsnum=33950507
|variant=0071
}}
{{omim
|id=141900
|rsnum=33950507
|variant=0276
}}{{ClinVar
|rsid=33950507
|Reversed=1
|FwdREF=G
|FwdALT=A,C,T
|REF=C
|ALT=A,G,T
|RSPOS=5248173
|CHROM=11
|dbSNPBuildID=126
|SSR=0
|SAO=1
|VP=0x050368000000000116110104
|GENEINFO=HBB:3043
|GENE_NAME=HBB
|GENE_ID=3043
|WGT=0
|VC=SNV
|CLNALLE=3
|CLNHGVS=NC_000011.9:g.5248173C>T
|CLNORIGIN=1
|CLNSRCID=
GTR000500319; GTR000500329; 141900.0071; 141900.0276
|CLNSIG=255
|CLNCUI=
|CLNACC=
RCV000016329.1; RCV000016330.24; RCV000016331.21; RCV000016332.24; RCV000016617.1
|Tags=RV;PM;PMC;S3D;SLO;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM;NOV
|CAF=0.9995; 0.0004591
|CLNDBN=Hemoglobin E; Beta-plus-thalassemia; Beta-e-thalassemia; Malaria, resistance to; HEMOGLOBIN T (CAMBODIA)
|CLNDSDB=MedGen:SNOMED_CT; MedGen
|CLNDSDBID=C0019024:83815000; C2720293
|CLNSRC=GTR; OMIM Allelic Variant
|COMMON=0
|Disease=Hemoglobin E; Beta-plus-thalassemia; Beta-e-thalassemia; Malaria; HEMOGLOBIN T (CAMBODIA)
}}{{PMID|19087310|OA=1
}} Microarray-based estimation of SNP allele-frequency in pooled DNA using the Langmuir kinetic model.

{{PMID Auto
|PMID=22673309
|Title=Variation in human genes encoding adhesion and proinflammatory molecules are associated with severe malaria in the Vietnamese.
|OA=1
}}

{{PMID Auto
|PMID=1878422
|Title=A Czechoslovakian teenager with Hb E-beta zero-thalassemia [IVS-I-1 (G----A)] complicated by the presence of an alpha-globin gene triplication.
}}

{{PMID Auto
|PMID=3728469
|Title=Haplotypes among Vietnamese hemoglobin E homozygotes including one with a gamma-globin gene triplication.
|OA=1
}}

{{PMID Auto
|PMID=6198908
|Title=Hemoglobin E in Europeans: further evidence for multiple origins of the beta E-globin gene.
|OA=1
}}

{{PMID Auto
|PMID=15481886
|Title=The 'hot-spot' of Hb E [beta26(B8)Glu-->Lys] in Southeast Asia: beta-globin anomalies in the Lao Theung population of southern Laos.
}}

{{PMID Auto
|PMID=1974422
|Title=Molecular basis of HbE-beta-thalassemia and the origin of HbE in northeast Thailand: identification of one novel mutation using amplified DNA from buffy coat specimens.
}}

{{on chip | 23andMe v4}}