{{Rsnum
|rsid=340874
|Chromosome=1
|position=213985913
|Orientation=minus
|GMAF=0.3806
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=PROX1-AS1
|Gene_s=PROX1-AS1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 18.8 | 50.0 | 31.2
| HCB | 46.7 | 41.6 | 11.7
| JPT | 38.9 | 52.2 | 8.8
| YRI | 84.4 | 15.6 | 0.0
| ASW | 70.2 | 28.1 | 1.8
| CHB | 46.7 | 41.6 | 11.7
| CHD | 39.4 | 51.4 | 9.2
| GIH | 13.9 | 61.4 | 24.8
| LWK | 87.3 | 12.7 | 0.0
| MEX | 27.6 | 56.9 | 15.5
| MKK | 85.3 | 14.7 | 0.0
| TSI | 19.6 | 46.1 | 34.3
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20081858
|Trait=Fasting glucose-related traits
|Title=New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
|RiskAllele=C
|Pval=7E-12
|OR=None
|ORtxt=None
|OA=1
}}

{{PharmGKB
|RSID=rs340874
|Name_s=
|Gene_s=PROX1
|Feature=
|Evidence=PubMed ID:20081858
|Annotation=Phenotype : In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting glucose level. Study size: 116,882. Significance metric(s): p = 6.6 x 10(-12). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281945
}}

{{PMID Auto
|PMID=21887289
|Title=Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin
|OA=1
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=4E-9
|OR=None
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs340874
|overall_frequency_n=36
|overall_frequency_d=128
|overall_frequency=0.28125
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24122840
|Title=PROX1 Gene Variant is Associated with Fasting Glucose Change After Antihypertensive Treatment
}}

{{PMID Auto
|PMID=23274905
|Title=Genetic and molecular insights into the role of PROX1 in glucose metabolism.
|OA=1
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}