{{Rsnum
|rsid=34210653
|Gene=ALOX15
|Chromosome=17
|position=4632019
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.01469
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(T;T)
|geno2=(C;T)
|geno3=(C;C)
|Gene_s=ALOX15
}}[[rs34210653]] is a SNP in the [[ALOX15]] gene, either encoding a threonine or a methionine at position 560 of the corresponding protein. This SNP is also known as T560M; the more common (C) allele encodes the threonine, and the rarer (T) allele encodes the methionine.

In mice, this protein appears to promote atherosclerosis, and mice completely lacking the entire gene are free of atherosclerosis. In contrast, [[rs34210653]](T;T) humans, who effectively have a non-functioning variant, do not show a statistically significant decreased risk for coronary artery disease. And [[rs34210653]](C;T) heterozygotes an increased risk of [[heart disease]] (adjusted odds ratio 1.62, p=0.02).{{PMID|17959182|OA=1
}}
{{ neighbor
| rsid = 916055
| distance = 480
}}
{{ neighbor
| rsid = 2619112
| distance = 71
}}

{{PMID Auto
|PMID=19046748
|Title=Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.
|OA=1
}}

{{GET Evidence
|gene=ALOX15
|aa_change=Thr560Met
|aa_change_short=T560M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs34210653
|overall_frequency_n=131
|overall_frequency_d=10758
|overall_frequency=0.012177
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.388
|nblosum100=2
|autoscore=2
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23906684
|Title=Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}