{{Rsnum
|rsid=342293
|Chromosome=7
|position=106731773
|Orientation=plus
|GMAF=0.3489
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 25.7 | 52.2 | 22.1
| HCB | 60.6 | 32.1 | 7.3
| JPT | 66.4 | 31.9 | 1.8
| YRI | 47.6 | 42.2 | 10.2
| ASW | 43.9 | 45.6 | 10.5
| CHB | 60.6 | 32.1 | 7.3
| CHD | 55.0 | 39.4 | 5.5
| GIH | 38.0 | 44.0 | 18.0
| LWK | 41.8 | 40.9 | 17.3
| MEX | 39.7 | 51.7 | 8.6
| MKK | 34.6 | 46.2 | 19.2
| TSI | 29.4 | 58.8 | 11.8
| HapMapRevision=28
}}{{PMID|19221038|OA=1
}} Influences blood volume and platelet count

{{PMID Auto GWAS
|PMID=19820697
|Trait=MPV
|Title=A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
|RiskAllele=G
|Pval=2E-33
|OR=0.02
|ORtxt=[0.013-0.017] fl increase
|OA=1
}}

{{PharmGKB
|RSID=rs342293
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19221038; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A novel variant on chromosome 7Q22.3 associated with mean platelet volume, counts and function. (Initial Sample Size: 1,221 individuals; Replication Sample Size: 7,365 individuals); (Region: 7q22.3; Reported Gene(s): Intergenic; Risk Allele: rs342293-G); (p-value= 1E-24).This variant is associated with Mean platelet volume.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739955
}}

{{PharmGKB
|RSID=rs342293
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19221038
|Annotation=This variant on chromosome 7q22.3 was associated with mean platelet volume, counts and function in GWAS in 8,586 healthy individuals.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA163522160
}}

{{PMID Auto GWAS
|PMID=22423221
|Trait=None
|Title=A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
|RiskAllele=C
|Pval=2E-8
|OR=4.0500
|ORtxt=None
|OA=1
}}

{{PMID|21193429|OA=1
}} Determinants of platelet count in humans.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs342293
|overall_frequency_n=51
|overall_frequency_d=126
|overall_frequency=0.404762
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22139419
  |Trait=Mean platelet volume
  |Title=New gene functions in megakaryopoiesis and platelet formation.
  |RiskAllele=G
  |Pval=7E-57
  |OR=.02
  |ORtxt=[0.015-0.019] ln(fl) increase
  |OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}