{{Rsnum
|rsid=34330
|Gene=CDKN1B
|Chromosome=12
|position=12717761
|Orientation=plus
|GMAF=0.3421
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CDKN1B,LOC101929220
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 54.9 | 38.9 | 6.2
| HCB | 28.1 | 49.6 | 22.2
| JPT | 23.9 | 50.4 | 25.7
| YRI | 30.6 | 51.7 | 17.7
| ASW | 41.1 | 42.9 | 16.1
| CHB | 28.1 | 49.6 | 22.2
| CHD | 33.0 | 47.7 | 19.3
| GIH | 64.4 | 27.7 | 7.9
| LWK | 25.9 | 59.3 | 14.8
| MEX | 63.8 | 29.3 | 6.9
| MKK | 48.1 | 46.2 | 5.8
| TSI | 55.9 | 39.2 | 4.9
| HapMapRevision=28
}}

[[Category:interesting]][[rs34330]] shows an association with [[breast cancer]] in a British study involving ~2300 patients. The odds ratio for the (T;T) vs (C;C) homozygotes is 1.22 (CI: 1.02-1.47, p=0.013).{{PMID|18174243|OA=1
}} 

{{PMID|15026335}} found a significant association between [[rs34330]] (-79C/T) and [[prostate cancer]]

{{PMID|21454826|OA=1
}} found higher odds for [[endometrial cancer]] among 1,200+ Chinese patients associated with [[rs34330]], with an odds ratio of 1.33 (CI: 1.06-1.66) and 1.51 (CI: 1.16-1.94) for the (C;T) and (T;T) genotypes, respectively, compared with the (C;C) genotype.

see also [http://www.genome.jp/dbget-bin/www_bget?omim+176807 omim 176807]

{{omim
|desc=CYCLIN-DEPENDENT KINASE INHIBITOR 1B; CDKN1B
|id=600778
|rsnum=34330
}}

{{PMID Auto
|PMID=20075119
|Title=Allelic variant at -79 (C&gt;T) in CDKNIB (p27Kip1) confers an increased risk of thyroid cancer and alters mRNA levels
}}

{{omim
|id=176807
|rsnum=34330
}}

{{PMID Auto
|PMID=16465622
|Title=Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
|OA=1
}}

{{PMID Auto
|PMID=17459456
|Title=A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
|OA=1
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=17908995
|Title=Genetic variants in cell cycle control pathway confer susceptibility to lung cancer.
}}

{{PMID Auto
|PMID=19124506
|Title=Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19258477
|Title=Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19667240
|Title=p27kip1-838C>A single nucleotide polymorphism is associated with restenosis risk after coronary stenting and modulates p27kip1 promoter activity.
}}

{{PMID Auto
|PMID=20452958
|Title=Single-nucleotide polymorphisms in the p53 signaling pathway.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23273568
  |Trait=Systemic lupus erythematosus
  |Title=Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
  |RiskAllele=C
  |Pval=5E-12
  |OR=1.19
  |ORtxt=
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}