{{Rsnum
|rsid=34336420
|Gene=KLF11
|Chromosome=2
|position=10047996
|Orientation=plus
|GMAF=0.007805
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=KLF11
}}{{omim
|id=603301
|rsnum=34336420
|variant=0002
}}

{{ClinVar
|rsid=34336420
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=10188123
|CHROM=2
|GMAF=0.0078
|dbSNPBuildID=126
|SSR=0
|SAO=1
|VP=0x050168000000040516110100
|GENEINFO=KLF11:8462
|GENE_NAME=KLF11
|GENE_ID=8462
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.10188123C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=603301.0002
|CLNSIG=5
|CLNCUI=C1864839
|CLNDBN=Maturity-onset diabetes of the young, type 7
|Disease=Maturity-onset diabetes of the young
|CLNACC=RCV000006872.1
|Tags=RV;PM;PMC;SLO;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9922; 0.007805
|CLNDSDB=MedGen:OMIM:Orphanet
|CLNDSDBID=C1864839:610508:552
|COMMON=1
}}

{{PMID Auto
|PMID=18593768
|Title=Association analysis of Kruppel-like factor 11 variants with type 2 diabetes in Pima Indians.
|OA=1
}}

{{GET Evidence
|gene=KLF11
|aa_change=Thr220Met
|aa_change_short=T220M
|impact=pathogenic
|qualified_impact=High clinical importance, Likely pathogenic
|inheritance=dominant
|quality_scores=Array
|dbsnp_id=rs34336420
|overall_frequency_n=165
|overall_frequency_d=10758
|overall_frequency=0.0153374
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=2
|n_articles_annotated=2
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|qualityscore_in_vitro=1
|qualitycomment_in_vitro=Y
|qualityscore_case_control=4
|qualitycomment_case_control=Y
|qualityscore_familial=!
|qualitycomment_familial=Y
|qualityscore_severity=4
|qualitycomment_severity=Y
|qualityscore_treatability=4
|qualitycomment_treatability=Y
|in_omim=Y
|pph2_score=0.858
|nblosum100=2
|autoscore=4
|webscore=N
|variant_evidence=2
|clinical_importance=1
|summary_short=Reported by Neve et al. to be a dominant cause of early-onset monogenic type II diabetes mellitus (maturity onset diabetes of the young). If true, carriers would be predicted to have a family history of diabetes. Florez et al. contradicted other findings in this gene made by Neve et al. for the Q62R polymorphism, and were unable to find any carriers of this rare variant (thus unable to investigate).
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}