{{Rsnum
|rsid=34536443
|Gene=TYK2
|Chromosome=19
|position=10352442
|Orientation=plus
|GMAF=0.01423
|Gene_s=TYK2
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{PMID Auto
|PMID=21140222
|Title=Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases
}}

{{PMID Auto
|PMID=18270328
|Title=Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
|OA=1
}}

{{PMID Auto
|PMID=19293837
|Title=Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.
|OA=1
}}

{{PMID Auto
|PMID=19888296
|Title=A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=20405052
|Title=The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
|OA=1
}}

{{PMID Auto
|PMID=21354972
|Title=Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility.
}}

{{GET Evidence
|gene=TYK2
|aa_change=Pro1104Ala
|aa_change_short=P1104A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs34536443
|overall_frequency_n=310
|overall_frequency_d=10758
|overall_frequency=0.0288158
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|pph2_score=1.0
|nblosum100=2
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23000200
|Title=TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.
}}

{{PMID Auto GWAS
  |PMID=24390342
  |Trait=Rheumatoid arthritis
  |Title=Genetics of rheumatoid arthritis contributes to biology and drug discovery.
  |RiskAllele=G
  |Pval=5E-16
  |OR=1.46
  |ORtxt=[1.33-1.60]
  }}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}