{{Rsnum
|rsid=34612342
|Gene=MUTYH
|Chromosome=1
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=MUTYH
|position=45332803
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=MUTYH
}}[[rs34612342]], also known as Tyr179Cys, is one of the two most common pathogenic mutations in the [[MUTYH]] gene. The normal allele, encoding the tyrosine, is [[rs34612342]](A), while [[rs34612342]](G) is the risk allele. [Mutation nomenclature according to Genbank accession number NM_001128425.1 c.536A>G, p.Tyr179Cys; alternative numbering can lead to this SNP also being called Tyr151Cys, Tyr152Cys, Tyr165Cys, or Tyr176Cys.] 

Germline bi-allelic mutations in the MUTYH gene increase the risk of developing multiple adenomatous polyps and [[colorectal cancer]]. {{PMID|11818965}}

{{PMID Auto
|PMID=20571908
|Title=MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study
}}

{{omim
|id=604933
|rsnum=34612342
|variant=0001
}}

{{ClinVar
|rsid=34612342
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=45332803
|CHROM=1
|dbSNPBuildID=126
|SSR=0
|SAO=1
|VP=0x050368000a05040102110110
|GENEINFO=MUTYH:4595
|GENE_NAME=MUTYH
|GENE_ID=4595
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.45332803T>C
|CLNSRC=Ambry Genetics; ClinVar; Emory University; GTR; GeneDx; GeneReviews; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=a6777; NM_001128425.1:c.536A>G; 7860; GTR000503285; GDX:492838; NBK107219; 604933.0001
|CLNSIG=5
|CLNCUI=C1837991; C0476089
|CLNDBN=MYH-associated polyposis; Endometrial carcinoma; not provided; Neoplastic Syndromes, Hereditary; AllHighlyPenetrant
|Disease=MYH-associated polyposis; Endometrial carcinoma; not provided; Neoplastic Syndromes; AllHighlyPenetrant
|CLNACC=RCV000005612.4; RCV000005613.1; RCV000079502.1; RCV000115766.2; RCV000121607.1
|Tags=RV;PM;PMC;S3D;SLO;NSM;REF;ASP;VLD;GNO;OTHERKG;LSD;OM;NOC
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet; MedGen:OMIM:SNOMED_CT; MedGen
|CLNDSDBID=NBK107219:C1837991:608456:ORPHA220460; C0476089:608089:254878006; C0027672
}}

{{PMID Auto
|PMID=21273643
|Title=In vitro functional effects of XPC gene rare variants from bladder cancer patients.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}