{{Rsnum
|rsid=34745240
|Gene=CYP4V2
|Chromosome=4
|position=186201178
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.02984
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CYP4V2
}}{{Venter SNP
|rsid=34745240
|allele=A
|frequency=
|uid=1103654656504
|type=heterozygous_SNP
|hugo=CYP4V2
|ensembl gene=ENSG00000145476
|ensembl transcript=ENST00000378802
|sift=TOLERATED
|disease=Defects in CYP4V2 are a cause of Bietti crystalline corneoretinal dystrophy (BCD) (MIM:210370). BCD is an autosomal recessive retinal dystrophy characterized by multiple glistening intraretinal crystals scattered over the fundus, a characteristic degeneration of the retina, and sclerosis of the choroidal vessels, ultimately resulting in progressive night blindness and constriction of the visual field. Most cases have similar crystals at the corneoscleral limbus. Clinically, BCD is progressive. Patients develop decreased vision, nyctalopia, and paracentral scotomata between the 2nd and 4th decade of life. Later, patients develop peripheral visual field loss and marked visual impairment, usually progressing to legal blindness by the 5th or 6th decade of life.
}}

{{GET Evidence
|gene=CYP4V2
|aa_change=Glu275Lys
|aa_change_short=E275K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs34745240
|overall_frequency_n=414
|overall_frequency_d=10758
|overall_frequency=0.038483
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.002
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}