{{Rsnum
|rsid=34778348
|Gene=LRRK2
|Chromosome=12
|position=40363526
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.009642
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LRRK2
}}{{Uniprot
|Accession=Q5S007	
|Name=Leucine-rich repeat serine/threonine-protein ...
|PMID=15541309; 16541075; 17974005; 16081470; 16321986; 16087219; 16269541; 16352719; 16532471; 15541308; 15726496; 15732108; 15852371; 16240353; 15880653; 15929036; 16251215; 16272164; 16333314; 16272257; 15680455; 15680456; 15680457; 15811454; 16001413; 16250030; 16172858; 16157901; 16247070; 16157908; 16157909; 15925109; 16298482; 16102999; 16533964; 17019612; 17344846; 18213618
}}In perfect contrast to another SNP also within the [[LRRK2]] gene, [[rs34637584]], this SNP, [[rs34778348]], is not found in Caucasian populations but is found in Asian populations.

A case-control study of 989 Chinese subjects concluded that the odds ratio for [[Parkinson's disease]] was 2.1 for [[rs34778348]](A) carriers (CI: 1.1-3.9, p = 0.014). This SNP was estimated to account for 4% of all Parkinson cases in this population.{{PMID|17019612}}

[http://blog.23andme.com/2009/12/18/new-study-suggests-lrrk2-g2019s-mutation-carriers-are-more-likely-to-have-postural-instability-and-gait-difficulty-type-of-parkinsons-disease/ 23andMe blog] [[Parkinson's disease]] 

{{PMID Auto
|PMID=19854095
|Title=The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population
}}

{{omim
|id=609007
|desc=LEUCINE-RICH REPEAT KINASE 2; LRRK2
|rsnum=34778348
}}

{{omim
|id=609007
|rsnum=34778348
|variant=0009
}}

{{PMID Auto GWAS
|PMID=22438815
|Trait=None
|Title=Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|RiskAllele=
|Pval=3E-21
|OR=2.2300
|ORtxt=None
|OA=1
}}

{{ClinVar
|rsid=34778348
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=40757328
|CHROM=12
|GMAF=0.0096
|dbSNPBuildID=126
|SSR=0
|SAO=1
|VP=0x050168000000000516130100
|GENEINFO=LRRK2:120892
|GENE_NAME=LRRK2
|GENE_ID=120892
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000012.11:g.40757328G>A
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;SLO;HD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;MTP;OM
|CAF=0.9904; 0.009642
|CLNACC=RCV000002020.1; RCV000032508.1
|CLNDBN=Parkinson disease 8, susceptibility to; Parkinson disease 8, autosomal dominant
|CLNDSDB=GeneReviews:GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1208:NBK1223:C1846862:607060:2828
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNSRCID=NBK1208; 609007.0009
|COMMON=1
|Disease=Parkinson disease 8; Parkinson disease 8
}}

{{PMID Auto
|PMID=19343804
|Title=LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.
|OA=1
}}

{{PMID Auto
|PMID=20186690
|Title=Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.
}}

{{GET Evidence
|gene=LRRK2
|aa_change=Gly2385Arg
|aa_change_short=G2385R
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs34778348
|overall_frequency_n=1
|overall_frequency_d=10756
|overall_frequency=9.2971e-05
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|in_omim=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=6
|autoscore=5
|webscore=N
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23651603
|Title=P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population
|OA=1
}}

{{PMID Auto
|PMID=16633828
|Title=A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}