{{Rsnum
|rsid=35180584
|Gene=RYR1
|Chromosome=19
|position=38505358
|Orientation=plus
|GMAF=0.0101
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=RYR1
}}{{omim
|id=180901
|rsnum=35180584
|variant=0023
}}

{{ClinVar
|rsid=35180584
|Reversed=0
|FwdREF=C
|FwdALT=G
|REF=C
|ALT=G
|RSPOS=38995998
|CHROM=19
|GMAF=0.0101
|dbSNPBuildID=126
|SSR=0
|SAO=1
|VP=0x050168000000140116110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38995998C>G
|CLNORIGIN=0
|CLNSIG=255
|Tags=PM;PMC;SLO;VLD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9899; 0.0101
|CLNACC=RCV000013857.1
|CLNDBN=Malignant hyperthermia
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1146:C0024591:145600:423
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=180901.0023
|COMMON=1
|Disease=Malignant hyperthermia
}}

[[rs35180584]], aka p.Thr2787Ser, may be an "aggravating" mutation associated with [[malignant hyperthermia]].{{PMID|14732627}}

{{PMID Auto
|PMID=16163667
|Title=Correlations between genotype and pharmacological, histological, functional, and clinical phenotypes in malignant hyperthermia susceptibility.
}}

{{GET Evidence
|gene=RYR1
|aa_change=Thr2787Ser
|aa_change_short=T2787S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs35180584
|overall_frequency_n=113
|overall_frequency_d=10758
|overall_frequency=0.0105038
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.973
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-2
|autoscore=4
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}