{{Rsnum
|rsid=356219
|Gene=SNCA
|Chromosome=4
|position=89716450
|Orientation=plus
|GMAF=0.4922
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 32.3 | 50.8 | 16.9
| HCB | 22.2 | 53.3 | 24.4
| JPT | 20.0 | 42.2 | 37.8
| YRI | 4.9 | 39.3 | 55.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 22.2 | 53.3 | 24.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs356219]], a tagging SNP in the [[SNCA]] gene for a [[Parkinson's disease]] associated haplotype, predicts the amount of [[SNCA]] (alpha-synuclein) mRNA found in post mortem substantia nigra and cerebellum brain tissue. {{PMID|18122487}}

{{PMID|21425343|OA=1
}} replicates the association of [[rs356219]] with late-onset [[Parkinson's disease]], calculating an odds ratio of 1.3 (CI: 1.13 - 1.5, p=2x10e-4) per [[rs356219]](G) allele among the 1145 patients from northern Spain studied.

{{PMID Auto
|PMID=18485051
|Title=Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.
}}

{{omim
|desc=MICROTUBULE-ASSOCIATED PROTEIN TAU; MAPT
|id=157140
|rsnum=356219
}}

{{omim
|desc=SYNUCLEIN, ALPHA; SNCA
|id=163890
|rsnum=356219
}}

{{PMID Auto
|PMID=21060011
|Title=SNCA Variant Associated With Parkinson Disease and Plasma {alpha}-Synuclein Level
|OA=1
}}
{{PMID Auto
|PMID=21159074
|Title=SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study
}}

{{PMID Auto GWAS
|PMID=21292315
|Trait=None
|Title=Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
|RiskAllele=G
|Pval=2E-47
|OR=1.2900
|ORtxt=[1.25-1.33]
|OA=1
}}

{{PMID Auto
|PMID=22349157
|Title=SNP rs356219 of the ?-synuclein (SNCA) gene is associated with Parkinson's disease in a Chinese Han population
}}

{{PMID Auto
|PMID=22669510
|Title=Age at Onset in LRRK2-Associated PD is Modified by SNCA Variants
}}

{{PMID Auto GWAS
|PMID=22438815
|Trait=None
|Title=Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|RiskAllele=
|Pval=6E-65
|OR=1.2900
|ORtxt=None
|OA=1
}}

{{PMID|15637659|OA=1
}} Linkage disequilibrium patterns and tagSNP transferability among European populations.

{{PMID|17683088}} Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.

{{PMID|18162487}} Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.

{{PMID|18606870}} Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.

{{PMID|18985386|OA=1
}} Genomewide association study for susceptibility genes contributing to familial Parkinson disease.

{{PMID|19063963|OA=1
}} Genetic susceptibility in Parkinson's disease.

{{PMID|19771175|OA=1
}} Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

{{PMID|19834617|OA=1
}} Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.

{{PMID|21391235|OA=1
}} Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.

{{PMID|22425546}} SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.

{{PMID Auto
|PMID=23737253
|Title=SNCA rs356219 variant increases risk of sporadic Parkinson's disease in Ethnic Chinese
}}

{{PMID Auto
|PMID=23962496
|Title=The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants
}}

{{PMID Auto
|PMID=23674386
|Title=SNCA: major genetic modifier of age at onset of Parkinson's disease.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}