{{Rsnum
|rsid=35667974
|Gene=IFIH1
|Chromosome=2
|position=162268127
|Orientation=plus
|GMAF=0.003214
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IFIH1
}}[[rs35667974]], also known as Ile923Val, is a SNP in the interferon induced with helicase C domain 1 [[IFIH1]] gene.

A recent study apparently found this SNP had the strongest association with [[type-1 diabetes]]; however, in a study of 3,000 European multiple sclerosis patients, no association was seen.{{PMID|20116863|OA=1
}}

{{PharmGKB
|RSID=rs35667974
|Name_s=
|Gene_s=IFIH1
|Feature=
|Evidence=PubMed ID:19264985
|Annotation=Rare variants (Minor allele frequency less than 3%) in candidate genes were identified by resequencing of exons and splice sites in pools of cases and controls. These were then tested in 8379 cases and 10,575 controls (from Great Britain) and in 3165 families from Europe and the USA, and the minor allele G of rs35667974 was found to be associated with a protective effect(case-control: 95% CI OR = 0.51; families: 95% CI RR = 0.60) against Diabetes Mellitus, Insulin-Dependent (combined p = 2.1 x 10( -16)).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 1
|Curation Level=Curated
|PharmGKB Accession ID=PA164889016
}}

{{PMID Auto
|PMID=20668468
|Title=Carriers of rare missense variants in IFIH1 are protected from psoriasis
|OA=1
}}

{{omim
|id=610155
|rsnum=35667974
}}

{{PMID Auto
|PMID=20736039
|Title=Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-? production in peripheral blood mononuclear cells of type 1 diabetes patients
}}

{{PMID Auto
|PMID=22110759
|Title=Polymorphisms in the Innate Immune IFIH1 Gene, Frequency of Enterovirus in Monthly Fecal Samples during Infancy, and Islet Autoimmunity
|OA=1
}}

{{PMID Auto
|PMID=19961590
|Title=The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.
|OA=1
}}

{{PMID Auto
|PMID=23144876
|Title=Enterovirus RNA in Peripheral Blood May Be Associated with the Variants of rs1990760, a Common Type 1 Diabetes Associated Polymorphism in IFIH1
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}