{{Rsnum
|rsid=35705950
|Chromosome=11
|position=1219991
|Orientation=plus
|GMAF=0.05234
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}[[rs35705950]] is a SNP located 3 kb upstream of the start of transcription from the mucin 5B [[MUC5B]] gene.

Two independent research groups both published articles in April 2011 associating the minor (T) allele of [[rs35705950]] with highly increased risk for interstitial [[pneumonia]] and/or [[pulmonary fibrosis]].

For interstitial pneumonia, the odds ratio for heterozygotes was 6.8 (CI: 3.9 - 12.0) and for homozygotes, 20.8 (CI: 3.8 - 113.7).{{PMID|21506741|OA=1
}}

For pulmonary fibrosis, the reported odds ratios for heterozygotes and homozygotes in one study were 9.0 (CI: 6.2 to 13.1) and 21.8 (CI: 5.1 to 93.5), respectively, and were 5.9 (CI: 4.4 - 7.8) and 9.7 (CI: 4.7 - 19.9) in the other.{{PMID|21506741|OA=1
}}{{PMID|21506748}}
{{PMID Auto
|PMID=23698811
|Title=MUC5B Promoter Variant Is Not Associated With Myositis-Related Interstitial Lung Disease
}}
{{PMID Auto
|PMID=23940607
|Title=The MUC5B Variant Is Associated with Idiopathic Pulmonary Fibrosis but Not with Systemic Sclerosis Interstitial Lung Disease in the European Caucasian Population
|OA=1
}}
{{PMID Auto
|PMID=24429156
|Title=Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study
}}
{{PMID Auto
|PMID=24434656
|Title=Association between MUC5 B and TERT polymorphisms and different interstitial lung disease phenotypes
}}{{PMID Auto
|PMID=23321605
|Title=Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis.
}}

{{PMID Auto
|PMID=23692170
|Title=MUC5B promoter polymorphism and interstitial lung abnormalities.
|OA=1
}}

{{PMID Auto
|PMID=23695349
|Title=Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.
}}
{{PMID Auto
|PMID=25184687
|Title=The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis
}}
{{PMID Auto
|PMID=25192356
|Title=Genome Sequencing of Idiopathic Pulmonary Fibrosis in Conjunction with a Medical School Human Anatomy Course
}}