{{Rsnum
|rsid=35753505
|Chromosome=8
|position=31616625
|Orientation=plus
|GMAF=0.3457
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}[[Rs35753505]] (SNP8NRG221533) is located within the 5'-flanking region of the [[NRG1]] (Neuregulin 1) gene.

[http://genes2brains2mentalhealth.wordpress.com/2008/06/05/genetic-risk-factor-for-schizophrenia-regulates-brain-function-in-healthy-people/ g2b2mh blog] [[rs35753505]](C;C) correlates with frontal brain having to working harder during a working memory task.

{{PMID|18455369}} [[personality traits]] - C allele carriers associated with higher (NEO-FFI) scores of neuroticism and lower scores of conscientiousness in a sample of 523 healthy individuals 

{{PMID|20036336}} The results suggest that subjects with risk alleles show hyperactivations in areas associated with elaborate episodic memory encoding and retrieval strategies.

{{PMID Auto
|PMID=19339916
|Title=An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis
}}
{{PMID Auto
|PMID=19856012
|Title=Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
|OA=1
}}

{{PMID Auto
|PMID=20182055
|Title=No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients
}}

{{PMID Auto
|PMID=18606232
|Title=Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals.
}}

{{PMID Auto
|PMID=19350564
|Title=Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals.
}}

{{PMID Auto
|PMID=19448847
|Title=Neuregulin 1 genetic variation and anterior cingulum integrity in patients with schizophrenia and healthy controls.
|OA=1
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{PMID Auto
|PMID=22424243
|Title=Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.
}}

{{PMID Auto
|PMID=23360725
|Title=Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample
}}

{{PMID Auto
|PMID=25106628
|Title=Drugs Targeting SNPrs35753505 of the NRG1 Gene may Prevent the Association of Schizophrenia in a Pakistani Population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}