{{Rsnum
|rsid=35767
|Gene=IGF1
|Chromosome=12
|position=102481791
|Orientation=minus
|GMAF=0.2819
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IGF1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 77.0 | 23.0 | 0.0
| HCB | 39.4 | 50.4 | 10.2
| JPT | 50.4 | 38.9 | 10.6
| YRI | 28.6 | 52.4 | 19.0
| ASW | 33.3 | 52.6 | 14.0
| CHB | 39.4 | 50.4 | 10.2
| CHD | 30.3 | 55.0 | 14.7
| GIH | 53.5 | 34.7 | 11.9
| LWK | 37.3 | 45.5 | 17.3
| MEX | 48.3 | 41.4 | 10.3
| MKK | 62.8 | 34.0 | 3.2
| TSI | 73.5 | 24.5 | 2.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=18761080
|Title=Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population
}}

{{PMID Auto
|PMID=19784788
|Title=Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk
}}

{{PMID Auto GWAS
|PMID=20081858
|Trait=Fasting glucose-related traits
|Title=New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
|RiskAllele=G
|Pval=2E-9
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=20490824
|Title=A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study
|OA=1
}}

{{PharmGKB
|RSID=rs35767
|Name_s=
|Gene_s=IGF1
|Feature=
|Evidence=PubMed ID:20081858
|Annotation=Phenotype 1: In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting insulin level. Study size: 94,590. Significance metric(s): p = 3.3 x 10(-8). Phenotype 2: In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with HOMA-IR (homeostasis model assessment of insulin resistance). Study size: 93,141. Significance metric(s): p = 2.2 x 10(-9). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281949
}}

{{PMID Auto
|PMID=22253814
|Title=A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme
|OA=1
}}

{{PMID Auto
|PMID=17300730
|Title=Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study.
|OA=1
}}

{{PMID Auto
|PMID=18199734
|Title=IGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study.
|OA=1
}}

{{PMID Auto
|PMID=18250100
|Title=Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy.
}}

{{PMID Auto
|PMID=18596909
|Title=IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).
|OA=1
}}

{{PMID Auto
|PMID=19124510
|Title=Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
|OA=1
}}

{{PMID Auto
|PMID=19147602
|Title=The -G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children.
}}

{{PMID Auto
|PMID=19240240
|Title=IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women.
|OA=1
}}

{{PMID Auto
|PMID=19551864
|Title=Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease.
|OA=1
}}

{{PMID Auto
|PMID=20039319
|Title=IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort.
|OA=1
}}

{{PMID Auto
|PMID=20199671
|Title=A microsatellite polymorphism in IGF1 gene promoter and longevity in a Han Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=21046444
|Title=Are elevated levels of IGF-1 caused by coronary arteriesoclerosis?: Molecular and clinical analysis.
|OA=1
}}

{{PMID Auto
|PMID=22354904
|Title=Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.
}}

{{PMID Auto
|PMID=22689104
|Title=No Effect of the IGF-1 Gene rs35767 and rs17032362 Polymorphisms in the Etiology of Idiopathic Short Stature.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs35767
|overall_frequency_n=93
|overall_frequency_d=128
|overall_frequency=0.726562
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=79
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23757194
|Title=Functional Interaction between SNPs and Microsatellite in the Transcriptional Regulation of Insulin-Like Growth Factor 1
}}

{{PMID Auto
|PMID=23800627
|Title=Associations of IGF-1 gene variants and milk protein intake with IGF-I concentrations in infants at age 6 months - results from a randomized clinical trial.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}