{{Rsnum
|rsid=35829419
|Gene=NLRP3
|Chromosome=1
|position=247425556
|Orientation=plus
|GMAF=0.02112
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=NLRP3
}}{{PMID Auto
|PMID=20182451
|Title=Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease
}}

{{PMID Auto
|PMID=21245836
|Title=The Missense Variation Q705K in CIAS1/NALP3/NLRP3 Gene and an NLRP1 Haplotype Are Associated With Celiac Disease
}}

{{ population diversity
| geno1 = (A;C)
| geno2 = (C;C)
| geno3 = 
| CEU | 11.7 | 88.3 | 0
| CHB | 0.0 | 100.0 | 0
| JPT | 2.2 | 97.8 | 0
| YRI | 0.0 | 100.0 | 0
}}
{{PMID Auto
|PMID=21621776
|Title=Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms
}}

{{PMID Auto
|PMID=22128899
|Title=Association study of CARD8 (p.C10X) and NLRP3 (p.Q705K) variants with rheumatoid arthritis in French and Tunisian populations.
}}

{{PMID Auto
|PMID=22524199
|Title=Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma.
}}

{{GET Evidence
|gene=NLRP3
|aa_change=Gln705Lys
|aa_change_short=Q705K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs35829419
|overall_frequency_n=369
|overall_frequency_d=10758
|overall_frequency=0.0343001
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-2
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23547871
|Title=Genetic variants in CARD8 but not in NLRP3 are associated with ankylosing spondylitis
}}

{{PMID Auto
|PMID=24142982
|Title=Genes involved in innate immunity associated with asbestos-related fibrotic changes
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}