{{Rsnum
|rsid=35859249
|Gene=TBC1D1
|Chromosome=4
|position=37902468
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.08081
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TBC1D1
}}Also known as the R125W variant, [[rs35859249]] is a SNP in the [[TBC1D1]] gene that has been associated with familiar - but not nonfamilial - [[obesity]] in several studies. The (C) allele encodes the (R), arginine, and the (T) allele encodes the (W), tryptophan.

In the first study to be published about this SNP, an analysis of primarily Utah families with [[obesity]] implicated the [[rs35859249]](T) allele as a predisposing factor. This allele segregated with affected females in a majority of the chromosome 4p15â€“14-linked obesity-prone pedigrees, was enriched on disease-associated haplotypes (P=0.000007), accounted for the majority of the linkage evidence at 4p15â€“14, and appeared to be the causal variant. This study also implied a gene-gene interaction including another [[obesity]] predisposition locus further down the same chromosome at 4q34â€“35.{{PMID|16893906}}

Subsequently, a study of 9,714 French Caucasian individuals, combining family-based and general population studies, confirmed an association with familial [[obesity]], yet did not find any association with body mass index or obesity in a large population-based cohort.{{PMID|18325908}}

{{omim
|id=608410
|rsnum=35859249
}}

{{GET Evidence
|gene=TBC1D1
|aa_change=Arg125Trp
|aa_change_short=R125W
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs35859249
|overall_frequency_n=784
|overall_frequency_d=10758
|overall_frequency=0.072876
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.65
|nblosum100=7
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}