{{Rsnum
|rsid=362272
|Gene=HTT
|Chromosome=4
|position=3233253
|Orientation=minus
|GMAF=0.2466
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HTT
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 52.2 | 37.2 | 10.6
| HCB | 45.3 | 43.8 | 10.9
| JPT | 42.5 | 46.0 | 11.5
| YRI | 99.3 | 0.7 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 45.3 | 43.8 | 10.9
| CHD | 42.1 | 44.9 | 13.1
| GIH | 70.3 | 28.7 | 1.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 48.3 | 39.7 | 12.1
| MKK | 99.4 | 0.6 | 0.0
| TSI | 51.0 | 45.1 | 3.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs362272
|Name_s=
|Gene_s=HTT
|Feature=
|Evidence=PubMed ID:19249009
|Annotation=This SNP is part of a haplogroup found to be associated with CAG repeat number expansion in Huntington disease (36 or more CAG repeats) in Europeans and also with intermediate expansion(27-35 repeats) in unaffected individuals(Europeans). This SNP itself was significantly associated(p < 0.0023) with the expansion.
|Drugs=
|Drug Classes=
|Diseases=Huntington Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA164918151
}}

{{PMID Auto
|PMID=19115052
|Title=Common variations in 4p locus are related to male completed suicide.
}}

{{PMID Auto
|PMID=19361997
|Title=Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.
|OA=1
}}

{{GET Evidence
|gene=HTT
|aa_change=Val2786Ile
|aa_change_short=V2786I
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs362272
|overall_frequency_n=2254
|overall_frequency_d=10454
|overall_frequency=0.215611
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=1
|n_articles_annotated=1
|gene_in_genetests=Y
|in_pharmgkb=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-4
|autoscore=3
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}