{{Rsnum
|rsid=363050
|Gene=SNAP25
|Chromosome=20
|position=10253609
|Orientation=plus
|GMAF=0.4729
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SNAP25
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 29.2 | 46.0 | 24.8
| HCB | 7.3 | 44.5 | 48.2
| JPT | 2.7 | 46.9 | 50.4
| YRI | 33.3 | 56.5 | 10.2
| ASW | 42.1 | 42.1 | 15.8
| CHB | 7.3 | 44.5 | 48.2
| CHD | 11.0 | 38.5 | 50.5
| GIH | 28.7 | 47.5 | 23.8
| LWK | 37.6 | 38.5 | 23.9
| MEX | 10.3 | 58.6 | 31.0
| MKK | 39.1 | 50.0 | 10.9
| TSI | 35.3 | 44.1 | 20.6
| HapMapRevision=28
}}SNPs in the [[SNAP25]] gene were initially {{PMID|17160701}} linked to [[intelligence]] but have failed to replicate {{PMID|19418213}}.

While now suspect, the original work can be found in {{PMID|16801949}}.

The (A;A) genotype averaged 2.84 PIQ points higher than the (A;G) genotype, which averages 2.8 PIQ points higher than the (G;G) genotype (p=0.0002). Variance in this SNP may account for 3.4% of the phenotypic variance in PIQ.{{PMID|16801949}}

[[rs363050]] is in close linkage with [[rs353016]], with r2 = 0.98, such that the [[rs363050(A)]] allele typically is linked to the [[rs353016(T)]] allele. For SNPs [[rs363039]] - [[rs363043]] - [[rs353016]], respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). {{PMID|17908175}}

[[Measures of Intelligence]]

{{PMID Auto
|PMID=22762387
|Title=Supporting the generalist genes hypothesis for intellectual ability/disability: the case of SNAP25
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}