{{Rsnum
|rsid=367643250
|Summary=metabolic syndrome (type-2 diabetes, coronary artery disease, obesity)
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Chromosome=19
|Orientation=plus
|Gene=DYRK1B
|position=39830443
|Gene_s=DYRK1B,MIR6719
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs367643250]], aka R102C, is a SNP in the [[DYRK1B]] gene on chromosome 19.

A study of three large families with coinheritance of early-onset [[coronary artery disease]], central [[obesity]], [[hypertension]], and [[type-2 diabetes]] led to the conclusion that the responsible mutation was a C>T change (on the reverse strand) for this SNP, leading to a missense change from an arginine (R) at amino acid position 102 to a cysteine (C). On the forward strand represented by [[rs367643250]] this means a change from a G>A.{{PMID|24827035}}