{{Rsnum
|rsid=3734091
|Gene=XRCC4
|Chromosome=5
|position=83204915
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.03719
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=XRCC4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 22.2 | 77.8
| JPT | 0.0 | 31.8 | 68.2
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 22.2 | 77.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 11.2 | 88.8
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 4.0 | 96.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19443403
|Title=Significant Association of an XRCC4 Single Nucleotide Polymorphism with Bladder Cancer Susceptibility in Taiwan
}}; note: no association seen for this SNP

{{DELETE}}

{{PMID Auto
|PMID=19729825
|Title=Lung cancer susceptibility and genetic polymorphism of DNA repair gene XRCC4 in Taiwan
}}

{{PMID Auto
|PMID=20332465
|Title=Significant association of XRCC4 single nucleotide polymorphisms with childhood leukemia in Taiwan
}}
{{PMID Auto
|PMID=20683005
|Title=Colorectal Cancer and Genetic Polymorphism of DNA Double-strand Break Repair Gene XRCC4 in Taiwan
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=17987338
|Title=A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan.
}}

{{PMID Auto
|PMID=18630527
|Title=Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan.
}}

{{GET Evidence
|gene=XRCC4
|aa_change=Ala247Ser
|aa_change_short=A247S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3734091
|overall_frequency_n=109
|overall_frequency_d=10758
|overall_frequency=0.010132
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.006
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23788213
|Title=Genetic Polymorphisms in DNA Repair Genes XRCC4 and XRCC5 and Aflatoxin B1-related Hepatocellular Carcinoma
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}