{{Rsnum
|rsid=3734254
|Gene=PPARD
|Chromosome=6
|position=35427233
|Orientation=plus
|GMAF=0.2952
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PPARD
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 6.2 | 31.9 | 61.9
| HCB | 6.7 | 35.6 | 57.8
| JPT | 2.7 | 37.5 | 59.8
| YRI | 33.3 | 52.1 | 14.6
| ASW | 35.7 | 44.6 | 19.6
| CHB | 6.7 | 35.6 | 57.8
| CHD | 11.0 | 45.0 | 44.0
| GIH | 3.0 | 33.7 | 63.4
| LWK | 39.8 | 31.5 | 28.7
| MEX | 0.0 | 22.4 | 77.6
| MKK | 35.3 | 51.0 | 13.7
| TSI | 7.8 | 35.3 | 56.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3734254
|Name_s=PPARD:rs3734254 C>T
|Gene_s=PPARD
|Feature=3' UTR
|Evidence=PubMed ID:20038957
|Annotation=Risk or phenotype-associated allele: T Phenotype: The PPAR delta SNP rs3734254 C>T was associated with positive clincial response (partial or complete response) to treatment. Study size: 47 Study population/ethnicity: Patients diagnosed with castration-resistant prostate cancer enrolled in a randomized phase II clinical trial comparing docetaxel to docetaxel with thalidomide. Significance metric(s): p = 0.0089 Type of association: PD; CO
|Drugs=docetaxel; thalidomide
|Drug Classes=
|Diseases=Prostatic Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA165111526
}}

{{PMID Auto
|PMID=16804087
|Title=Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
}}

{{PMID Auto
|PMID=16979821
|Title=PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3734254
|overall_frequency_n=71
|overall_frequency_d=128
|overall_frequency=0.554688
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23907334
|Title=Genetic Variants of Peroxisome Proliferator-Activated Receptor δ Are Associated with Gastric Cancer
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}