{{Rsnum
|rsid=3734354
|Gene=SIM1
|Chromosome=6
|position=100420903
|Orientation=minus
|GMAF=0.197
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=LOC102724406,SIM1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 2.7 | 23.9 | 73.5
| HCB | 17.5 | 52.6 | 29.9
| JPT | 21.6 | 52.3 | 26.1
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 7.0 | 93.0
| CHB | 17.5 | 52.6 | 29.9
| CHD | 17.4 | 46.8 | 35.8
| GIH | 2.0 | 23.8 | 74.3
| LWK | 0.0 | 0.9 | 99.1
| MEX | 5.2 | 36.2 | 58.6
| MKK | 0.0 | 1.3 | 98.7
| TSI | 4.9 | 26.5 | 68.6
| HapMapRevision=28
}}{{PMID Auto
|PMID=20075856
|Title=Analysis of the SIM1 Contribution to Polygenic Obesity in the French Population
|OA=1
}}

{{PMID Auto
|PMID=21512513
|Title=Replication and extension of association between common genetic variants in SIM1 and human adiposity
}}

{{PMID Auto
|PMID=17357083
|Title=Medical sequencing at the extremes of human body mass.
|OA=1
}}

{{PMID Auto
|PMID=19401419
|Title=Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.
|OA=1
}}

{{PMID Auto
|PMID=21671989
|Title=Dosing equation for tacrolimus using genetic variants and clinical factors.
|OA=1
}}

{{GET Evidence
|gene=SIM1
|aa_change=Pro352Thr
|aa_change_short=P352T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3734354
|overall_frequency_n=1072
|overall_frequency_d=10758
|overall_frequency=0.0996468
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.365
|genetests_testable=Y
|nblosum100=4
|autoscore=2
|n_web_uneval=8
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}