{{Rsnum
|rsid=3735273
|Gene=DDC
|Chromosome=7
|position=50529166
|Orientation=minus
|GMAF=0.2787
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DDC
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 35.4 | 58.5
| HCB | 18.8 | 42.9 | 38.3
| JPT | 15.5 | 47.3 | 37.3
| YRI | 15.3 | 49.3 | 35.4
| ASW | 10.7 | 48.2 | 41.1
| CHB | 18.8 | 42.9 | 38.3
| CHD | 19.3 | 52.3 | 28.4
| GIH | 0.0 | 0.0 | 0.0
| LWK | 6.5 | 32.4 | 61.1
| MEX | 0.0 | 0.0 | 0.0
| MKK | 6.4 | 46.8 | 46.8
| TSI | 5.9 | 36.3 | 57.8
| HapMapRevision=28
}}
per OMIM, Ma et al. (2005) {{PMID|15879433}} found two different DDC haplotypes associated with nicotine dependence in African Americans and European Americans (with measures of smoking quantity [SQ], heaviness of [[smoking]] index [HSI], and the Fagerstrom test for ND [FTND])
*in African Americans, [[rs921451]](T), [[rs3735273]](G), [[rs1451371]](T), [[rs2060762]](G), all three measures sig. associated after correction for multiple testing
*in European Americans, [[rs921451]](T), [[rs3735273]](G), [[rs1451371]](T), [[rs3757472]](G), which showed a sig. assoc. w/ the SQ and FTND score

{{omim
|desc=TOBACCO [[Addiction]], SUSCEPTIBILITY TO
|id=188890
|rsnum=3735273
}}

{{omim
|desc=DOPA DECARBOXYLASE; DDC
|id=107930
|rsnum=3735273
}}

{{PharmGKB
|RSID=rs3735273
|Name_s=
|Gene_s=DDC
|Feature=
|Evidence=PubMed ID:15879433
|Annotation=A study on 2037 smokers and non-smokers from 602 nuclear families of African- or European-American ancestry found first evidence for the involvement of DDC in the susceptibility to nicotine dependence. This variant in the DDC gene is part of two haplotypes, a protective T-G-T-G haplotype for rs921451-rs3735273-rs1451371-rs2060762 in the African-American sample and a high-risk T-G-T-G haplotype for rs921451-rs3735273-rs1451371-rs3757472 in the European-American sample.
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162316617
}}

{{PMID Auto
|PMID=17184203
|Title=DOPA decarboxylase gene is associated with nicotine dependence.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3735273
|overall_frequency_n=3061
|overall_frequency_d=10758
|overall_frequency=0.284532
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=28
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}