{{Rsnum
|rsid=3735972
|Gene=CNGB3
|Chromosome=8
|position=86575970
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.08127
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CNGB3
}}[[rs3735972]], also known as E755G or Glu755Gly, is a SNP in the  cyclic nucleotide gated-channel beta 3 [[CNGB3]] gene.

Although this SNP causes an amino acid substitution, it is not known to have medical consequences, unlike some other SNPs in this same gene which are known to lead to various forms of color-blindness.{{PMID|10958649}}

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 84.1 | 15.9 | 0.0
| HCB | 88.3 | 11.7 | 0.0
| JPT | 76.1 | 20.4 | 3.5
| YRI | 87.8 | 12.2 | 0.0
| ASW | 89.5 | 10.5 | 0.0
| CHB | 88.3 | 11.7 | 0.0
| CHD | 92.7 | 6.4 | 0.9
| GIH | 91.1 | 8.9 | 0.0
| LWK | 93.6 | 6.4 | 0.0
| MEX | 87.9 | 10.3 | 1.7
| MKK | 91.7 | 7.7 | 0.6
| TSI | 87.3 | 11.8 | 1.0
| HapMapRevision=28
}}

{{Venter SNP
|rsid=3735972
|allele=C
|frequency=
|uid=1103652373042
|type=heterozygous_SNP
|hugo=CNGB3
|ensembl gene=ENSG00000170289
|ensembl transcript=ENST00000320005
|sift=TOLERATED
|disease=Defects in CNGB3 are a cause of achromatopsia 3 (ACHM3) (MIM:262300); also known as Pingelapese blindness. ACHM3 is a congenital complete achromatopsia and is distinct from total colorblindness mainly because of the consistent concurrence of severe myopia.
}}

{{GET Evidence
|gene=CNGB3
|aa_change=Glu755Gly
|aa_change_short=E755G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3735972
|overall_frequency_n=890
|overall_frequency_d=10758
|overall_frequency=0.0827291
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.11
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=6
|autoscore=3
|n_web_uneval=2
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}