{{Rsnum
|rsid=3736265
|Gene=PPARGC1A
|Chromosome=4
|position=23813084
|Orientation=plus
|GMAF=0.1088
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PPARGC1A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 12.4 | 87.6
| HCB | 3.6 | 31.4 | 65.0
| JPT | 0.9 | 27.4 | 71.7
| YRI | 0.7 | 16.4 | 82.9
| ASW | 1.8 | 7.0 | 91.2
| CHB | 3.6 | 31.4 | 65.0
| CHD | 0.9 | 33.9 | 65.1
| GIH | 4.0 | 20.8 | 75.2
| LWK | 0.0 | 12.7 | 87.3
| MEX | 1.7 | 20.7 | 77.6
| MKK | 1.9 | 11.5 | 86.5
| TSI | 0.0 | 13.7 | 86.3
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19828207
|Title=Evaluation of the association between the PPARGC1A genetic polymorphisms and type 2 diabetes in Han Chinese population
}}

{{PMID Auto
|PMID=16642433
|Title=Polymorphism in maternal LRP8 gene is associated with fetal growth.
|OA=1
}}

{{PMID Auto
|PMID=17187763
|Title=Analysis of PGC-1alpha variants Gly482Ser and Thr612Met concerning their PPARgamma2-coactivation function.
}}

{{PMID Auto
|PMID=18162502
|Title=PPARGC1A variation associated with DNA damage, diabetes, and cardiovascular diseases: the Boston Puerto Rican Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18588668
|Title=Association between PPARGC1A polymorphisms and the occurrence of nonalcoholic fatty liver disease (NAFLD).
|OA=1
}}

{{PMID Auto
|PMID=18599530
|Title=Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients.
|OA=1
}}

{{PMID Auto
|PMID=19133136
|Title=The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.
|OA=1
}}

{{PMID Auto
|PMID=20426853
|Title=Association and interaction of PPAR-complex gene variants with latent traits of left ventricular diastolic function.
|OA=1
}}

{{GET Evidence
|gene=PPARGC1A
|aa_change=Thr612Met
|aa_change_short=T612M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3736265
|overall_frequency_n=620
|overall_frequency_d=10758
|overall_frequency=0.0576315
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23741228
|Title=Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia
|OA=1
}}

{{PMID Auto
|PMID=24383721
|Title=A single nucleotide polymorphism in the coding region of PGC-1alpha is a male-specific modifier of Huntington disease age-at-onset in a large European cohort
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | Illumina Human 1M}}