{{Rsnum
|rsid=3736309
|Gene=AQP5
|Chromosome=12
|position=49964271
|Orientation=plus
|GMAF=0.1561
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=AQP5,LOC101927318
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 77.9 | 19.5 | 2.7
| HCB | 38.0 | 48.9 | 13.1
| JPT | 50.4 | 36.3 | 13.3
| YRI | 0.0 | 0.0 | 0.0
| ASW | 93.0 | 7.0 | 0.0
| CHB | 38.0 | 48.9 | 13.1
| CHD | 37.6 | 45.0 | 17.4
| GIH | 58.4 | 40.6 | 1.0
| LWK | 99.1 | 0.9 | 0.0
| MEX | 82.8 | 17.2 | 0.0
| MKK | 96.8 | 3.2 | 0.0
| TSI | 76.5 | 21.6 | 2.0
| HapMapRevision=28
}}[[rs3736309]] is a SNP in the aquaporin 5 ([[AQP5]]) gene. Among other roles, the aquaporin proteins play a critical role in the maintenance of normal lung water homeostasis.

A study of 332 Chinese Han [[Chronic obstructive pulmonary disease]] (COPD) patients and 373 unrelated, age-matched controls concluded that carriers of a [[rs3736309]](G) allele had a lower risk of COPD than [[rs3736309]](A;A) carriers, with an odds ratio of 0.44 (CI: 0.307-0.631). {{PMID|18853286}}

{{PMID Auto
|PMID=23352976
|Title=Polymorphisms in genes encoding aquaporins 4 and 5 and estrogen receptor alpha in patients with Meniere's disease and sudden sensorineural hearing loss.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}