{{Rsnum
|rsid=3737965
|Gene=CLCN6
|Chromosome=1
|position=11806394
|Orientation=minus
|GMAF=0.05188
|Gene_s=CLCN6,MTHFR
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 89.2 | 10.8 | 0.0
| HCB | 82.2 | 15.6 | 2.2
| JPT | 82.2 | 17.8 | 0.0
| YRI | 90.5 | 9.5 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 82.2 | 15.6 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3737965
|Name_s=MTHFR SNP in promoter not linked to 677T>C or 1298A>C; rs3737965C>T
|Gene_s=MTHFR, CLCN6
|Feature=Intron, Intron
|Evidence=PubMed ID:19683694
|Annotation=Risk or phenotype-associated allele: C Phenotype: The C variant of rs3737965 was associated with Spina Bifida in a transmission disequilibrium test. Study size: 610 families (329 trios, 281 duos) Study population/ethnicity: Patients affected with Spina Bifida and their parents; Houston, TX; Los Angeles, CA; Toronto, ON, Canada Significance metric(s): p = 0.0076 Type of association: CO
|Drugs=
|Drug Classes=
|Diseases=Neural Tube Defects; Spina Bifida Cystica
|Curation Level=Curated
|PharmGKB Accession ID=PA165223221
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3737965
|overall_frequency_n=317
|overall_frequency_d=10392
|overall_frequency=0.0305042
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}