{{Rsnum
|rsid = 3738099
|Gene = ALPL
|geno1 = (C;C)
|geno2 = (C;T)
|geno3 = (T;T)
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|Chromosome=1
|position=21568242
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Status=Merged
|Merged=3200254
|Gene_s=ALPL
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 2.7 | 20.4 | 77.0
| HCB | 18.4 | 52.2 | 29.4
| JPT | 30.6 | 53.2 | 16.2
| YRI | 11.6 | 39.7 | 48.6
| ASW | 5.3 | 40.4 | 54.4
| CHB | 18.4 | 52.2 | 29.4
| CHD | 27.5 | 46.8 | 25.7
| GIH | 5.9 | 27.7 | 66.3
| LWK | 7.3 | 34.5 | 58.2
| MEX | 12.1 | 36.2 | 51.7
| MKK | 2.6 | 28.2 | 69.2
| TSI | 0.0 | 20.6 | 79.4
| HapMapRevision=28
}}

{{PMID|17195227}} A study of 201 Canadian [[ankylosing spondylitis]] families concluded the ALPL (TNAP) haplotype G-G-T for SNPs [[rs3767155]]-[[rs3738099]]-[[rs1780329]], respectively, is significantly associated with the disease but only in men.

{{PMID|18769922}} A study of 353 Chinese ankylosing spondylitis patients found no significant difference in allele, genotype or haplotype frequencies for this SNP in either case-control or family-based association studies, which indicated that the TNAP (also known as ALPL) gene is unlikely to play a major role in the susceptibility to ankylosing spondylitis in the Chinese Han population.

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}