{{Rsnum
|rsid=3738401
|Gene=DISC1
|Chromosome=1
|position=231694549
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.2805
|Gene_s=DISC1,MAP1LC3C
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 15.2 | 42.0 | 42.9
| HCB | 4.4 | 36.0 | 59.6
| JPT | 4.5 | 49.1 | 46.4
| YRI | 0.0 | 16.3 | 83.7
| ASW | 8.8 | 35.1 | 56.1
| CHB | 4.4 | 36.0 | 59.6
| CHD | 5.5 | 39.4 | 55.0
| GIH | 5.0 | 32.0 | 63.0
| LWK | 1.8 | 17.3 | 80.9
| MEX | 10.3 | 55.2 | 34.5
| MKK | 2.6 | 26.3 | 71.2
| TSI | 9.8 | 44.1 | 46.1
| HapMapRevision=28
}}

[[rs3738401]] is a SNP in the [[DISC1]] gene, known as R264Q.

{{PMID|16389590}} Associated with [[schizophrenia]]

{{PMID|17673452}} 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish [[Bipolar disorder]]  families.
*[[rs751229]](T) and [[rs3738401]](A) was over-transmitted to males with psychotic disorder. 
*under-transmitted [[rs821616]](T) and [[rs1411771]](T)
*The risk haplotype for psychotic disorder also associated to perseverations (P = 0.035; for [[rs751229]] alone P = 0.0012), and a protective haplotype G-T-G with [[rs1655285]] in addition to auditory attention (P = 0.0059). 

{{omim
|id=605210
|desc=DISRUPTED IN SCHIZOPHRENIA 1; DISC1
|rsnum=3738401
}}

{{omim
|id=605210
|rsnum=3738401
|variant=0001
}}

{{PMID Auto
|PMID=15386212
|Title=Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=17997036
|Title=Association study of polymorphisms between DISC1 and schizophrenia in a Korean population.
}}

{{PMID Auto
|PMID=19197363
|Title=A genome-wide investigation of SNPs and CNVs in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19255581
|Title=Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
}}

{{PMID Auto
|PMID=19300510
|Title=The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{PMID Auto
|PMID=20531374
|Title=Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.
}}

{{PMID Auto
|PMID=21483430
|Title=Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=21878470
|Title=Effect of DISC1 on the P300 Waveform in Psychosis.
|OA=1
}}

{{GET Evidence
|gene=DISC1
|aa_change=Arg264Gln
|aa_change_short=R264Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3738401
|overall_frequency_n=2778
|overall_frequency_d=10758
|overall_frequency=0.258226
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{ClinVar
|ALT=A
|CAF=0.7195; 0.2805
|CHROM=1
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.231694549G>A
|CLNSIG=1
|COMMON=1
|FwdALT=A
|FwdREF=G
|GENEINFO=TSNAX-DISC1:100303453; DISC1:27185
|GENE_ID=100303453; 27185
|GENE_NAME=TSNAX-DISC1; DISC1
|REF=G
|RSPOS=231694549
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;NSM;REF;INT;ASP;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|VC=SNV
|VP=0x050168080a0517051f110100
|WGT=1
|dbSNPBuildID=107
|rsid=3738401
|CLNACC=RCV000084637.1
|CLNDBN=not provided
|Disease=not provided
|CLNORIGIN=0
|CLNSRC=ClinVar
|CLNSRCID=NM_001164556.1:c.68-55377G>A; NM_018662.2:c.791G>A; NR_028393.1:n.1512G>A
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}