{{Rsnum
|rsid=3740199
|Gene=ADAM12
|Chromosome=10
|position=128019025
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.4518
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 15.6 | 54.7 | 29.7
| HCB | 24.4 | 55.6 | 20.0
| JPT | 29.5 | 36.4 | 34.1
| YRI | 15.9 | 52.4 | 31.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 24.4 | 55.6 | 20.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|19268722}} Authors of this study of just 189 subjects conclude that rs3740199 polymorphism may affect occurrence of knee [[osteoarthritis]] and its progression (p = 0.018), and even speculate that this SNP's effect is "remarkably gender-dependent and anatomical site-specific". Of course, another alternative is that it's just another case of overinterpretation based on having too few samples for a properly powered SNP study. Only time will tell.

{{PMID|16385451|OA=1
}} A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

{{GET Evidence
|gene=ADAM12
|aa_change=Gly48Arg
|aa_change_short=G48R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3740199
|overall_frequency_n=6197
|overall_frequency_d=10758
|overall_frequency=0.576036
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=63
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.001
|nblosum100=6
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23491141
|Title=Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study
}}

{{PMID Auto
|PMID=23606964
|Title=Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}