{{Rsnum
|rsid=3741378
|Gene=SIPA1
|Chromosome=11
|position=65641466
|Orientation=minus
|GMAF=0.2309
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SIPA1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.8 | 25.9 | 72.3
| HCB | 13.9 | 40.1 | 46.0
| JPT | 18.6 | 38.9 | 42.5
| YRI | 13.7 | 38.4 | 47.9
| ASW | 10.5 | 35.1 | 54.4
| CHB | 13.9 | 40.1 | 46.0
| CHD | 11.0 | 43.1 | 45.9
| GIH | 0.0 | 14.9 | 85.1
| LWK | 10.0 | 40.0 | 50.0
| MEX | 0.0 | 22.8 | 77.2
| MKK | 6.4 | 42.3 | 51.3
| TSI | 2.0 | 31.4 | 66.7
| HapMapRevision=28
}}[http://7thspace.com/headlines/320435/polymorphisms_of_the_sipa1_gene_and_sporadic_breast_cancer_susceptibility.html news] [[breast cancer]]  [[rs3741378]](C) associated with increased breast cancer incidence. [[rs931127]]  and [[rs746429]] did not show significant associations with breast cancer incidence, yet were associated with lymph node metastasis in the previous study

{{PMID Auto
|PMID=19089925
|Title=Genetic variation in SIPA1 in relation to breast cancer risk and survival after breast cancer diagnosis.
|OA=1
}}

{{PMID Auto
|PMID=19765277
|Title=Polymorphisms of the SIPA1 gene and sporadic breast cancer susceptibility.
|OA=1
}}

{{GET Evidence
|gene=SIPA1
|aa_change=Ser182Phe
|aa_change_short=S182F
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3741378
|overall_frequency_n=1928
|overall_frequency_d=10756
|overall_frequency=0.179249
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.27
|nblosum100=5
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23771732
|Title=Case-only analyses of the associations between polymorphisms in the metastasis-modifying genes BRMS1 and SIPA1 and breast tumor characteristics, lymph node metastasis, and survival.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}