{{Rsnum
|rsid=3745516
|Gene=SPIB
|Chromosome=19
|position=50423485
|Orientation=plus
|GMAF=0.4968
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SPIB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 5.3 | 36.3 | 58.4
| HCB | 53.3 | 41.6 | 5.1
| JPT | 72.6 | 26.5 | 0.9
| YRI | 53.1 | 41.5 | 5.4
| ASW | 47.4 | 36.8 | 15.8
| CHB | 53.3 | 41.6 | 5.1
| CHD | 67.0 | 30.3 | 2.8
| GIH | 12.9 | 52.5 | 34.7
| LWK | 42.7 | 46.4 | 10.9
| MEX | 25.9 | 34.5 | 39.7
| MKK | 49.4 | 36.5 | 14.1
| TSI | 5.9 | 42.2 | 52.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20639880
|Trait=Primary biliary cirrhosis
|Title=Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
|RiskAllele=A
|Pval=8E-11
|OR=1.46
|ORtxt=[NR]
|OA=1
}}

Each A allele of this SNP in the SPIB gene is associated with 1.46 times higher odds of [[primary biliary cirrhosis]]. {{PMID|20639880|OA=1
}}

{{PMID Auto GWAS
|PMID=21399635
|Trait=None
|Title=Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
|RiskAllele=A
|Pval=2E-13
|OR=1.3800
|ORtxt=[1.32-1.44]
|OA=1
}}

{{PMID Auto
|PMID=20639879
|Title=Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
|OA=1
}}

{{PMID Auto
|PMID=21506939
|Title=Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}