{{Rsnum
|rsid=3746319
|Gene=ZNF224
|Chromosome=19
|position=44108078
|Orientation=minus
|GMAF=0.3664
|Gene_s=CEACAMP2,ZNF224
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 67.3 | 28.3 | 4.4
| HCB | 27.4 | 51.1 | 21.5
| JPT | 30.1 | 48.7 | 21.2
| YRI | 21.9 | 48.6 | 29.5
| ASW | 28.1 | 50.9 | 21.1
| CHB | 27.4 | 51.1 | 21.5
| CHD | 25.9 | 59.3 | 14.8
| GIH | 55.4 | 35.6 | 8.9
| LWK | 25.0 | 51.9 | 23.1
| MEX | 34.5 | 43.1 | 22.4
| MKK | 21.8 | 46.2 | 32.1
| TSI | 68.6 | 25.5 | 5.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3746319
|Name_s=
|Gene_s=ZNF225, ZNF224
|Feature=
|Evidence=PubMed ID:19118814
|Annotation=This variant is significantly associated with late-onset Alzheimer disease (LOAD) in a GWAS study with 492 LOAD cases and 498 cognitive controls using Illumina's HumanHap550 beadchip.
|Drugs=
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA162363836
}}

{{PMID Auto
|PMID=20574532
|Title=Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=21480501
|Title=Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease.
|OA=1
}}

{{GET Evidence
|gene=ZNF224
|aa_change=Lys640Glu
|aa_change_short=K640E
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3746319
|overall_frequency_n=7673
|overall_frequency_d=10758
|overall_frequency=0.713237
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=72
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}