{{Rsnum
|rsid=3746544
|Gene=SNAP25
|Chromosome=20
|position=10306436
|Orientation=minus
|GMAF=0.2934
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=SNAP25
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 38.9 | 46.0 | 15.0
| HCB | 62.8 | 32.8 | 4.4
| JPT | 44.2 | 47.8 | 8.0
| YRI | 51.0 | 42.2 | 6.8
| ASW | 63.2 | 33.3 | 3.5
| CHB | 62.8 | 32.8 | 4.4
| CHD | 59.6 | 34.9 | 5.5
| GIH | 55.4 | 36.6 | 7.9
| LWK | 45.5 | 48.2 | 6.4
| MEX | 55.2 | 43.1 | 1.7
| MKK | 50.6 | 42.3 | 7.1
| TSI | 43.1 | 49.0 | 7.8
| HapMapRevision=28
}}{{PMID|19132710}} SNPs nominally associated with [[schizophrenia]] ([[rs3787283]], [[rs3746544]]) were the same as those previously demonstrated to be associated with [[ADHD]] but with the opposite alleles, allowing the intriguing hypothesis that genetic variation at SNAP25 may be differentially associated with both schizophrenia and [[ADHD]]

When comparing pooled results of multiple [[ADHD]] studies, only rs3746544(A) was found to have a significant association (p=0.028) with slightly increased risk (OR 1.15 at 95%) of [[ADHD]]. {{PMID Auto
|PMID=19721846
|Title=Candidate genes involved in neural plasticity and the risk for [[attention-deficit hyperactivity disorder]]: a meta-analysis of 8 common variants
|OA=1
}}

{{PMID|17325713}} Support for the MnlI polymorphism of SNAP25; a Korean ADHD case-control study.

{{PMID|17455213}} Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder.

{{PMID|12660803}} Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder.

{{PMID Auto
|PMID=16380908
|Title=Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
|OA=1
}}

{{PMID Auto
|PMID=21557260
|Title=Haplotyping of putative microRNA-binding sites in the SNAP-25 gene.
}}

{{PMID Auto
|PMID=21996783
|Title=Role of SNAP25 explored in eastern Indian attention deficit hyperactivity disorder probands.
}}

{{PMID Auto
|PMID=23872233
|Title=The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample
}}

{{PMID Auto
|PMID=24164654
|Title=Genetic variants of synaptic vesicle and presynaptic plasma membrane proteins in idiopathic generalized epilepsy
}}

{{PMID Auto
|PMID=22940547
|Title=Preliminary evidence for association between schizophrenia and polymorphisms in the regulatory Regions of the ADRA2A, DRD3 and SNAP-25 Genes.
}}

{{PMID Auto
|PMID=23593184
|Title=DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex.
|OA=1
}}

{{PMID Auto
|PMID=25054019
|Title=Meta-analyses of 10 polymorphisms associated with the risk of schizophrenia
}}

{{PMID Auto
|PMID=25229170
|Title=Association of SNAP-25, SLC6A2, and LPHN3 With OROS Methylphenidate Treatment Response in Attention-Deficit/Hyperactivity Disorder
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}