{{Rsnum
|rsid=3748079
|Gene=ITPR3
|Chromosome=6
|position=33620370
|Orientation=minus
|GMAF=0.1781
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ITPR3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.1 | 33.6 | 59.3
| HCB | 3.6 | 26.3 | 70.1
| JPT | 4.4 | 19.5 | 76.1
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 10.5 | 89.5
| CHB | 3.6 | 26.3 | 70.1
| CHD | 2.8 | 25.7 | 71.6
| GIH | 7.9 | 45.5 | 46.5
| LWK | 0.0 | 0.9 | 99.1
| MEX | 3.4 | 46.6 | 50.0
| MKK | 0.0 | 3.8 | 96.2
| TSI | 2.9 | 39.2 | 57.8
| HapMapRevision=28
}}
[[rs3748079]] is a SNP in the promoter region of the [[ITPR3]] gene; it is also known as -1990C>T.

[[rs3748079]] has been linked to increased risk for systemic lupus erythematosus ([[SLE]]) in two independent Japanese case-control samples (p=0.0000000178 with odds ratio of 1.88, CI:1.51-2.35). Individuals with risk genotypes of both [[rs3748079]] and [[rs3095870]], in the [[ITPR3]] and [[NKX2.5]] genes, respectively, have even high risk for [[SLE]] (odds ratio 5.77).{{PMID|18219441}}

This particular SNP also revealed associations with [[rheumatoid arthritis]] (RA) (p=0.0084 with odds ratio of 1.23, CI:1.05-1.43) and with [[Graves' disease]] (GD) (p=0.00036 with odds ratio of 1.57, CI:1.22-2.02).{{PMID|18219441}}

Note that the orientation of this SNP as published is reversed compared to the dbSNP entry.

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS; SLE
|id=152700
|rsnum=3748079
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}