{{Rsnum
|rsid=3750848
|Gene=ARMS2
|Chromosome=10
|position=124215315
|Orientation=minus
|GMAF=0.2736
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 60.2 | 38.9 | 0.9
| HCB | 28.5 | 56.9 | 14.6
| JPT | 38.9 | 43.4 | 17.7
| YRI | 56.5 | 38.8 | 4.8
| ASW | 57.9 | 40.4 | 1.8
| CHB | 28.5 | 56.9 | 14.6
| CHD | 33.0 | 53.2 | 13.8
| GIH | 42.6 | 44.6 | 12.9
| LWK | 49.1 | 40.9 | 10.0
| MEX | 51.7 | 43.1 | 5.2
| MKK | 49.4 | 44.9 | 5.8
| TSI | 71.6 | 28.4 | 0.0
| HapMapRevision=28
}}[http://www.nature.com/ng/journal/v40/n7/full/ng.170.html nature] [[age related macular degeneration]] is associated with five highly correlated SNPs ([[rs10490924]], [[rs3750848]], [[rs3793917]], [[rs11200638]] and [[rs932275]]; r2 < 0.88) showed strongest association with AMD (2.72 < OR < 2.86)

{{PMID Auto
|PMID=19933195
|Title=Analysis of six genetic risk factors highly associated with AMD in the region surrounding ARMS2 and HTRA1 on chromosome 10q26
}}

{{PMID Auto
|PMID=21878851
|Title=ASSOCIATION BETWEEN HIGH-RISK DISEASE LOCI AND RESPONSE TO ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR TREATMENT FOR WET AGE-RELATED MACULAR DEGENERATION
}}

{{PMID|16642439|OA=1
}} Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration.

{{PMID|17884985|OA=1
}} A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration.

{{PMID|20140183|OA=1
}} Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.

{{PMID|20157352|OA=1
}} Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population.

{{PMID Auto GWAS
  |PMID=23577725
  |Trait=Age-related macular degeneration (extreme sampling)
  |Title=Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.
  |RiskAllele=C
  |Pval=3E-29
  |OR=3.12
  |ORtxt=[2.55-3.80]
  |OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}