{{Rsnum
|rsid=3751143
|Gene=P2RX7
|Chromosome=12
|position=121184501
|Orientation=minus
|GMAF=0.1919
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=P2RX7
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 2.7 | 30.1 | 67.3
| HCB | 2.9 | 41.9 | 55.1
| JPT | 4.5 | 41.1 | 54.5
| YRI | 0.0 | 18.4 | 81.6
| ASW | 0.0 | 14.0 | 86.0
| CHB | 2.9 | 41.9 | 55.1
| CHD | 6.4 | 46.8 | 46.8
| GIH | 6.9 | 38.6 | 54.5
| LWK | 0.9 | 16.4 | 82.7
| MEX | 8.8 | 28.1 | 63.2
| MKK | 6.4 | 25.0 | 68.6
| TSI | 9.9 | 35.6 | 54.5
| HapMapRevision=28
}}{{PMID Auto
|PMID=20488797
|Title=P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages
|OA=1
}}

{{PMID Auto
|PMID=22662160
|Title=A Common Missense Variant in the ATP Receptor P2X7 Is Associated with Reduced Risk of Cardiovascular Events
|OA=1
}}

{{ClinVar
|rsid=3751143
|Reversed=1
|FwdREF=T
|FwdALT=G
|REF=A
|ALT=C
|RSPOS=121622304
|CHROM=12
|GMAF=0.1928
|dbSNPBuildID=107
|SSR=0
|SAO=0
|VP=0x050168000a0115051f110100
|GENEINFO=P2RX7:5027
|GENE_NAME=P2RX7
|GENE_ID=5027
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000012.11:g.121622304A>C
|CLNSIG=1
|Tags=RV;PM;PMC;SLO;NSM;REF;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8081; 0.1919
|COMMON=1
}}

{{PMID Auto
|PMID=17705862
|Title=Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
|OA=1
}}

{{PMID Auto
|PMID=19319666
|Title=Genetics of the P2X7 receptor and human disease.
|OA=1
}}

{{PMID Auto
|PMID=19700502
|Title=Synopsis and synthesis of candidate-gene association studies in chronic lymphocytic leukemia: the CUMAGAS-CLL information system.
}}

{{PMID Auto
|PMID=19838818
|Title=Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function.
|OA=1
}}

{{PMID Auto
|PMID=20196868
|Title=Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.
|OA=1
}}

{{GET Evidence
|gene=P2RX7
|aa_change=Glu496Ala
|aa_change_short=E496A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3751143
|overall_frequency_n=1603
|overall_frequency_d=10758
|overall_frequency=0.149005
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23144326
  |Trait=Chronic obstructive pulmonary disease-related biomarkers
  |Title=Genome-Wide Association Analysis of Blood Biomarkers in Chronic Obstructive Pulmonary Disease.
  |RiskAllele=C
  |Pval=4E-6
  |OR=NR
  |ORtxt=NR
  |OA=1
}}

{{PMID Auto
|PMID=22776862
|Title=Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.
|OA=1
}}

{{PMID Auto
|PMID=23435013
|Title=Association of P2X7R gene polymorphisms with systemic lupus erythematosus in a Chinese population.
}}

{{PMID Auto
|PMID=23648388
|Title=Association of P2X7 receptor gene polymorphisms with sporadic Parkinson's disease in a Han Chinese population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}