{{Rsnum
|rsid=3754777
|Gene=STK39
|Chromosome=2
|position=168159404
|Orientation=minus
|GMAF=0.1942
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=STK39
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.5 | 21.4 | 74.1
| HCB | 6.6 | 45.3 | 48.2
| JPT | 3.6 | 31.2 | 65.2
| YRI | 0.7 | 22.4 | 76.9
| ASW | 5.3 | 26.3 | 68.4
| CHB | 6.6 | 45.3 | 48.2
| CHD | 6.5 | 40.7 | 52.8
| GIH | 8.9 | 27.7 | 63.4
| LWK | 0.0 | 15.5 | 84.5
| MEX | 5.3 | 43.9 | 50.9
| MKK | 0.6 | 20.5 | 78.8
| TSI | 4.9 | 32.4 | 62.7
| HapMapRevision=28
}}[[rs3754777]] is a SNP in the serine threonine kinase 39 [[STK39]] gene.

A study of ~1,000 Amish originally identified [[rs3754777]] and another SNP also in the [[STK39]] gene, [[rs6749447]], as being significantly associated with [[hypertension]]. This association was then found to also hold in patient data analyzed from the Framingham Heart Study and the Diabetes Genetics Initiative. On average, each minor allele, in this case [[rs3754777]](A), is associated with 2.0 mmHg higher systolic blood pressure and a 1.0 mm Hg higher diastolic pressure.{{doi|10.1073/pnas.0808358106}}

{{PMID Auto
|PMID=20003416
|Title=STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression
|OA=1
}}
{{PMID Auto
|PMID=20889219
|Title=STK39 is an independent risk factor for male hypertension in Han Chinese
}}

{{PMID Auto
|PMID=19114657
|Title=From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
|OA=1
}}

{{PMID Auto
|PMID=21228780
|Title=Novel genetic variations associated with salt sensitivity in the Korean population.
}}

[[High Blood Pressure (Hypertension)]]

{{PMID Auto
|PMID=23408757
|Title=Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans
|OA=1
}}

{{PMID Auto
|PMID=23591986
|Title=Influence of obesity on association between genetic variants identified by genome-wide association studies and hypertension risk in Chinese children.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}