{{Rsnum
|rsid=3758149
|Gene=GGH
|Chromosome=8
|position=63039169
|Orientation=minus
|GMAF=0.2337
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GGH
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 43.1 | 49.2 | 7.7
| HCB | 60.0 | 35.6 | 4.4
| JPT | 39.5 | 48.8 | 11.6
| YRI | 74.6 | 22.2 | 3.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 60.0 | 35.6 | 4.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3758149
|Name_s=GGH: promoter -401C>T
|Gene_s=GGH
|Feature=NA
|Evidence=PubMed ID:15564880
|Annotation=Risk or phenotype-associated allele: TT genotype. Phenotype: Patients with the GGH 401TT genotype were 4.8-fold (p = 0.002) more likely to have methotrexate polyglutamate (MTXPG3-5) levels below the group median compared to patient carriers of the 401CC or CT genotype. Study size: 226. Study population/ethnicity: Adult rheumatoid arthritis patients from Tennessee and Florida who received low-dose MTX therapy for at least 3 months. Significance metric(s): OR = 4.8; p = 0.002. Type of association: PD, GN
|Drugs=methotrexate
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA165109582
}}

{{PMID Auto
|PMID=22018726
|Title=Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study
|OA=1
}}
{{PMID Auto
|PMID=16826517
|Title=Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells.
|OA=1
}}

{{PMID Auto
|PMID=18842806
|Title=Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3758149
|overall_frequency_n=36
|overall_frequency_d=128
|overall_frequency=0.28125
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24908438
|Title=Influence of genetic polymorphisms of FPGS, GGH, and MTHFR on serum methotrexate levels in Chinese children with acute lymphoblastic leukemia
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}